National Football League

2023 NFL Week 1 odds, predictions: Picks, lines, results for every game

Updated Sep. 12, 2023 12:20 a.m. ET

The 2023 NFL regular season opened with some great games and performances this week.

How did you fare on your wagers?

In the season's first game, the defending Super Bowl champion Kansas City Chiefs dropped a game at home against the Detroit Lions on Thursday, 21-20.

The weekend ended with the New York Jets beating the Buffalo Bills 22-16 in overtime despite quarterback Aaron Rodgers suffering an injury and exiting the game on a cart.

Here's a look at the lines and final betting results for Week 1.

49ers' defense dominates in blowout victory over Steelers

The San Francisco 49ers' defense forced two turnovers and held the Steelers to 246 yards in the 30-7 victory.

COMPLETED GAMES

Jets 22, Bills 16 (OT)

Point spread: Jets (+2) cover by winning outright
Moneyline: Jets win as +108 underdogs (bet $10 to win $20.80 total); Bills were -126 favorites (bet $10 to win $17.94 total)
Total scoring Over/Under: Under 45.5 points scored by both teams combined (38)

Cowboys 40, Giants 0

Point spread: Cowboys (-3.5) cover by winning by more than 3.5 points (40)
Moneyline: Cowboys win as -172 favorites (bet $10 to win $15.81 total); Giants were +144 underdogs (bet $10 to win $24.40 total)
Total scoring Over/Under: Under 44.5 points scored by both teams combined (40)

Eagles 25, Patriots 20

Point spread: Eagles (-3.5) cover by winning by more than 3.5 points (5)
Moneyline: Eagles win as -176 favorites (bet $10 to win $15.68 total); Patriots were +138 underdogs (bet $10 to win $23.80 total)
Total scoring Over/Under: Over 44.5 points scored by both teams combined (45)

Dolphins 36, Chargers 34

Point spread: Dolphins (+3) cover by winning outright
Moneyline: Dolphins win as +138 underdogs (bet $10 to win $23.80 total); Chargers were -164 favorites (bet $10 to win $16.10 total);
Total scoring Over/Under: Over 50.5 points scored by both teams combined (70)

Rams 30, Seahawks 13

Point spread: Rams (+4.5) cover by winning outright
Moneyline: Rams win as +176 underdogs (bet $10 to win $27.60 total); Seahawks were -210 favorites (bet $10 to win $14.76 total);
Total scoring Over/Under: Under 45.5 points scored by both teams combined (43)

Packers 38, Bears 20

Point spread: Packers (+1.5) cover by winning outright
Moneyline: Packers win as +106 underdogs (bet $10 to win $20.60 total); Bears were -124 favorites (bet $10 to win $18.06 total)
Total scoring Over/Under: Over 40.5 points scored by both teams combined (58)

Raiders 17, Broncos 16

Point spread: Raiders (+3.5) cover by winning outright
Moneyline: Raiders win as +138 underdogs (bet $10 to win $23.80 total); Broncos were -164 favorites (bet $10 to win $16.10 total);
Total scoring Over/Under: Under 43.5 points scored by both teams combined (33)

49ers 30, Steelers 7

Point spread: 49ers (-1.5) cover by winning by more than 1.5 points (23)
Moneyline: 49ers win as -118 favorites (bet $10 to win $18.47 total); Steelers were +100 underdogs (bet $10 to win $20 total)
Total scoring Over/Under: Under 41.5 points scored by both teams combined (37)

Buccaneers 20, Vikings 17

Point spread: Buccaneers (+4.5) cover by winning outright
Moneyline: Buccaneers win as +166 underdogs (bet $10 to win $26.60 total); Vikings were -198 favorites (bet $10 to win $15.05 total);
Total scoring Over/Under: Under 44.5 points scored by both teams combined (37)

Browns 24, Bengals 3

Point spread: Browns (+1.5) cover by winning outright
Moneyline: Browns win as -102 underdogs (bet $10 to win $19.80 total); Bengals were -116 favorites (bet $10 to win $18.62 total);
Total scoring Over/Under: Under 46.5 points scored by both teams combined (27)

Falcons 24, Panthers 10

Point spread: Falcons (-3.5) cover by winning by more than 3.5 points (14)
Moneyline: Falcons win as -186 favorites (bet $10 to win $15.38 total); Panthers win as +156 underdogs (bet $10 to win $25.60 total)
Total scoring Over/Under: Under 40.5 points scored by both teams combined (34)

Jaguars 31, Colts 21

Point spread: Jaguars (-3.5) cover by winning by more than 3.5 points (10)
Moneyline: Jaguars win as -188 favorites (bet $10 to win $15.32 total); Colts win as +158 underdogs (bet $10 to win $25.80 total)
Total scoring Over/Under: Over 45.5 points scored by both teams combined (52)

Commanders 20, Cardinals 16

Point spread: Cardinals (+6.5) cover by losing by fewer than 6.5 points (4)
Moneyline: Commanders win as -310 favorites (bet $10 to win $13.23 total); Cardinals were +250 underdogs (bet $10 to win $35 total)
Total scoring Over/Under: Under 38.5 points scored by both teams combined (36)

Washington Commanders

WAS

Saints 16, Titans 15

Point spread: Titans (+3) cover by losing by fewer than 3 points (1)
Moneyline: Saints win as -152 favorites (bet $10 to win $16.58 total); Titans were +128 underdogs (bet $10 to win $22.80 total)
Total scoring Over/Under: Under 41.5 points scored by both teams combined (31)

Ravens 25, Texans 9

Point spread: Ravens (-9.5) cover by winning by more than 9.5 points (16)
Moneyline: Ravens win as -420 favorites (bet $10 to win $12.38 total); were Texans +330 underdogs (bet $10 to win $43 total)
Total scoring Over/Under: Under 43.5 points scored by both teams combined (34)

Lions 21, Chiefs 20

Point spread: Lions (+6.5) cover by winning outright
Moneyline: Lions win as +235 underdogs (bet $10 to win $33.50 total); Chiefs were -290 favorites (bet $10 to win $13.45 total)
Total scoring Over/Under: Under 54.5 points scored by both teams combined (41)

A few other marquee matchups stood out on the Week 1 card.

Dallas Cowboys -3.5 at New York Giants WIN

Can the Cowboys finally make a deep playoff run worth mentioning? Or is Dallas doomed to exit stage left in the divisional round again, or worse, the wild-card round?

The Boys are 3.5-favorites (opened at -2.5) at NFC East nemesis New York in Week 1. An opening-week win on enemy turf could be exactly what America's Team needs to silence doubters and boost quarterback Dak Prescott's confidence as the season gets underway.

Miami Dolphins +3 at Los Angeles Chargers WIN

Dolphins at Chargers will be another fun contest to watch featuring two high-flying offenses. This will be a battle between Tua Tagovailoa — a quarterback whose season was plagued with injuries in 2022, and Justin Herbert — a player who FOX Sports Betting Analyst Sammy P likes to win MVP.

Stay tuned to FOX Sports to keep up with the latest in the NFL!