Buffalo Bills vs. 49ers: Odds, Injury/Weather Report, Predictions

Buffalo Bills

Oct 2, 2016; Foxborough, MA, USA; Buffalo Bills quarterback Tyrod Taylor (5) throws during the second half of the Buffalo Bills 16-0 win over the New England Patriots at Gillette Stadium. Mandatory Credit: Winslow Townson-USA TODAY Sports

The Buffalo Bills will host the San Francisco 49ers on Sunday at 1:00 PM for their second straight meeting with a team from California.

The Buffalo Bills will look to make it four wins in a row when they play the San Francisco 49ers on Sunday at New Era Field. It’s been three weeks now since Anthony Lynn became our offensive coordinator and it’s proven to be the right move.

The Bills’ defense has been the highlight of this team all year and we have the NFL’s sacks leader and tackles leader to show for it. On the other hand, our offense has been a work in progress. However, they seem to be getting better each week and continue to fine-tune whatever needs to be worked on.

During their three game winning streak, LeSean McCoy has been tearing defenses up. In that span, he has rushed for 330 yards and two touchdowns, although he hasn’t found the endzone on the ground in the past two weeks. He has been a big part of the passing game as well, accumulating 11 receptions, 52 yards and one TD during the win streak.

Speaking of the passing game, it has been hurting without the talents of Sammy Watkins out there. However, we received good news this week on his injury — which won’t be needing surgery. The team hasn’t ruled out a possible return to the field this season and continues to keep optimism high on his return.

On the defensive side of the ball, we have yet to see Stephon Gilmore live up to his top-cornerback salary he is asking for. He hasn’t been bad out there, but definitely hasn’t been worthy of a huge contract. If anything, we should be more concerned about wrapping up Zach Brown and Lorenzo Alexander (for however amount of years he has left).

All in all, the defense has been getting the job done over the past few weeks. They now have three defensive touchdowns on the season, a boatload of sacks and a very nice turnover ratio to compliment that.

Let’s take a look at the Vegas odds for their game on Sunday vs. the 49ers.

Spread: 49ers (+9) vs. Bills (-9)

Money Line: 49ers (+300) vs. Bills (-300)

Over/Under: 45

Buffalo Bills

Jan 3, 2016; Orchard Park, NY, USA; Buffalo Bills quarterback Tyrod Taylor (5) drops to pass as tackle Cordy Glenn (77) blocks New York Jets outside linebacker Lorenzo Mauldin (55) during the first quarter at Ralph Wilson Stadium. Mandatory Credit: Kevin Hoffman-USA TODAY Sports

The Buffalo Bills could be without their star defensive tackle Marcell Dareus for yet another game.

It looks like we are going to have a cloudy day out there today, but hopefully won’t see any rain until later in the day after the Buffalo Bills‘ game is over.

Here’s a look at the weather report for Sunday’s game in Orchard Park, NY.

Partly Cloudy

Temp: 71°

Precipitation: 15%

Humidity: 68%

Wind: 16 mph

Now, let’s dive into the injury report and see who the Buffalo Bills and 49ers could be without on Sunday.

Buffalo Bills

Dec 27, 2015; Orchard Park, NY, USA; Buffalo Bills defensive tackle Marcell Dareus (99) down after suffering a shoulder injury during the first half against the Dallas Cowboys at Ralph Wilson Stadium. Mandatory Credit: Kevin Hoffman-USA TODAY Sports

Buffalo Bills’ Injury Report

Zach Brown (foot) – Questionable

Corbin Bryant (ankle) – Questionable

Charles Clay (knee) – Questionable

Marcell Dareus (hamstring) – Doubtful

Cordy Glenn (ankle) – Questionable

Cyrus Kouandjio (ankle) – Questionable

Patrick Lewis (knee) – Questionable

Colton Schmidt (right quad) – Questionable

Corey White (shoulder) – Questionable

Aaron Williams (ankle) – Questionable

Buffalo Bills vs. 49ers

Sep 12, 2016; Santa Clara, CA, USA; San Francisco 49ers outside linebacker Eli Harold (58) and outside linebacker Ahmad Brooks (55) react in the game against the Los Angeles Rams in the second quarter at Levi

San Francisco 49ers’ Injury Report

Ahmad Brooks (groin) – Questionable

DeForest Buckner (foot) – Questionable

Glenn Dorsey (knee) – Questionable

Jaquiski Tartt (quadricep) – Questionable

Jimmie Ward (quadricep) – Doubtful

Buffalo Bills

Nov 23, 2015; Foxborough, MA, USA; Buffalo Bills head coach Rex Ryan speaks a to a referee during the second half at Gillette Stadium. Mandatory Credit: Mark L. Baer-USA TODAY Sports

The Buffalo Bills could improve to 4-2 after this week. Let’s see a few predictions from me and my co-editor for this game.

A lot could happen this week.

Upcoming Schedule


The Buffalo Bills could win their fourth straight game this season after an 0-2 start.

LeSean McCoy can continue his rise up the NFL rushing leaderboard. Zach Brown could continue his reign as the tackles leader, Lorenzo Alexander could regain his reign as the sacks leader — with Von Miller’s sack in Thursday’s game, he is now 0.5 sacks above Alexander.

The Bills have a lot to prove this season and after a shaky start, they found themselves a step behind. However, they never let that get to their heads and bounced back in beautiful fashion.

Now, they will have to get past the struggling 49ers — who have named Colin Kaepernick their starter for the game. He will be making his first start of the season.

Here’s a look at my co-editor’s predictions for the game:

Dennis Moody: BuffaLowDown Co-Editor

The Buffalo Bills will win 24-10, Adolphus Washington will get 2 sacks, LeSean McCoy will have 150 yards on the day and will be the 2nd leading rusher in the league after the week is over — trailing only rookie Ezekiel Elliott.

Now, to my predictions for the game:

Ryan Brennan: BuffaLowDown Co-Editor

The Buffalo Bills will win their fourth straight game in a 33-13 dominant victory vs. the 49ers. Although mobile, Kaepernick will have a tough day finding time to throw as the Bills’ defense will combine for 5 sacks on the day. Lorenzo Alexander will reclaim his spot atop the league’s sack leaders and Zach Brown will finish the game with 9+ tackles. Dan Carpenter will have another extra point blocked.

Leave your predictions in the comments section located below!

Go Bills!

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