Columbus will play Real Salt Lake in an all-Major League Soccer quarterfinal of the CONCACAF Champions League.
The Crew will host the first leg of the series from Feb. 22-24, following Monday's draw. Salt Lake will host the second leg from March 1-3.
In a pair of all-Mexican matchups, Cruz Azul plays Santos Laguna and Toluca meets Monterrey. Costa Rica's Saprissa plays Honduras' Olimpia in the other quarterfinal.
The Columbus-Salt Lake winner advances to a semifinal against Olimpia or Saprissa on March 15-17 and April 5-7. The two-leg final is April 19-21 and April 26-28.