Brazilian giants Cruzeiro strolled past Argentinian champions Estudiantes 3-0 to confirm their qualification to the last 16 as top seeds.
Both sides had already qualified from Group Seven, but the win means Cruzeiro will play the second leg of all the ties in the knockout stages at home.
Thiago Ribeiro finished from a Wallyson assist to open the scoring in the 11th minute, before Wallyson showed great individual skill to double the lead in first-half stoppage time.
Estudiantes pressed for an equaliser but found Cruzeiro keeper Fabio in fine form.
Indeed, he even started the move which led to the third goal, passing to Everton who set up Gilberto to finish seven minutes from time.
"We played good football tonight. We still have a lot to give in this championship," Wallyson told Fox Sports.
"The team counter-attacked very well and we are very happy to have won in Argentina."
Estudiantes forward Leandro Gonzalez said: "Cruzeiro were a very tough team. They are strong candidates to win the championship.
"When we had chances, we didn't score. They did. Now in the last 16, the real Libertadores starts."
Also in Group Seven, Colombian side Tolima claimed a 2-0 away win over Guarani in Paraguay.
Danny Santoya opened the scoring three minutes after the interval before Luis-Francisco Closa widened the gap in the 68th minute.
Both sides had already been eliminated.