Samme Givens scored 19 of his 21 points in the second half as Drexel came back from an eight-point halftime deficit to defeat James Madison 67-64 on Saturday night.
The teams will meet again on March 5 in the first round of the Colonial Athletic Association Tournament in Richmond, Va.
Chris Fouch sank four free throws in the final 41 seconds for the Dragons (16-15, 11-7) after the game was tied for the 11th time, 62-62.
The second half remained tight after Drexel used an 11-1 run to get a 33-33 tie with 14:37 remaining after the Dukes 12-19, 4-14) had led 32-22.
Givens was 9-for-11 from the free throw line and Fouch 5-for-5 as the Dragons made 21 of 24 in the game, 19-for-21 in the second half, to James Madison's 13-for-19 overall.
Drexel also had a 40-28 rebounding edge.
Pierre Curtis led James Madison with 15 points and Denzell Bowles had 13.