Perine rushed for 1,713 yards his freshman year, the sixth-best total in school history, and 21 touchdowns. He ran for a FBS-record 427 yards against Kansas that season, a mark that still stands. As a sophomore, he had 1,349 yards and 16 touchdowns.
This season, despite missing three games and most of a fourth with a leg injury, he rushed for 1,060 yards and 12 touchdowns. His best performance was a 239-yard effort against Oklahoma State.