Newgarden started fourth on a restart with eight laps left, and got around Wickens with three laps left on the 1.022-mile oval. The defending series champion raced to his eighth IndyCar victory and third on an oval, finishing 2.994 seconds ahead of Wickens.
Wickens was making his first oval start, driving for Schmidt Peterson.
Power jumped from fourth to first during the stops to lead the field to green on Lap 50. After leading the first 43 laps, Bourdais had to serve a drive-through penalty for hitting the crew member.
Josef Newgarden was running second, followed by Robert Wickens and Ryan Hunter-Reay.
Sebastien Bourdais and Simon Pagenaud took the green flag on an all-French front row Saturday night at ISM Raceway.
Bourdais is coming off a victory in the IndyCar opener on the streets of St. Petersburg, about nine months after the Dale Coyne Racing driver fractured his pelvis and right hip in a crash during Indianapolis 500 qualifying. The four-time CART season champion has 37 race victories.
Pagenaud won last year in the desert for his first oval victory. Team Penske teammate Will Power started third, followed by Andretti Autosports’ Alexander Rossi and Schmidt Peterson’s Canadian duo of James Hinchcliffe and Robert Wickens.
The 250-lap race is the first oval event for the sleek new car designed to improve competition and cut costs.