Mississippi St beats Southern Miss 49-0

Updated Mar. 5, 2020 1:37 a.m. ET

foxsports

STARKVILLE, Miss. (AP) -- Dak Prescott threw for a career-high 284 yards and four touchdowns, including two to De'Runnya Wilson, and Mississippi State cruised to a 49-0 victory over Southern Mississippi in the season-opener for both teams on Saturday night.

The Bulldogs dominated from the outset, needing nine plays on the opening drive to cruise 87 yards downfield. Prescott ended the drive by finding Wilson for a wide open 25-yard touchdown pass -- the first of many offensive highlights.

A few Mississippi State hiccups kept the game close early, but the Bulldogs scored three touchdowns in the second quarter and gained 387 yards in the first half for a 28-0 lead.

Southern Miss struggled in every facet, gaining just 283 total yards and giving up 550. The Golden Eagles' best chance to score was a 30-yard field goal attempt that was blocked and then returned by MSU's Jay Hughes for a touchdown.