There are too many NFL games each week to try to keep track of all that's truly going on. With that in mind, we thought we'd help you thin the herd a bit by picking out the one game each week that you can absolutely miss, and (spoiler alert) the San Francisco 49ers are prominently involved.
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Patriots at Browns, Week 5
Tom Brady (as you may have heard) has been suspended for the first four games of the regular season. His first game back under center will be Week 5 in Cleveland against a Browns team that's once again projected to be among the league's worst. While Josh Gordon will play for the first time after serving his suspension, too, and while checking out Brady's first action of the season might certainly be tempting, a final score of 55-3 in New England's favor wouldn't at all be a surprise given the circumstances.
Getty ImagesMaddie Meyer
Eagles at Bears, Week 2
Some would argue that there is no bad football in the season's second week, but putting this matchup on Monday night as our only choice doesn't inspire much confidence. The Eagles have a new head coach and a mess at the quarterback position, while the Bears' combination of a bad offensive line and a secondary that might be even worse makes this a game we'd rather just skip.
Getty ImagesDarren McCollester
Browns at Dolphins, Week 3
RGIII may surprise us in his second life with the Browns, but with Josh Gordon still suspended at this point, a trip to face the Dolphins in Miami just a few weeks into the season after Ryan Tannehill led the league in yards lost due to sacks doesn't exactly scream "exciting matchup."
Getty ImagesDylan Buell
Jaguars at Bills, Week 12
Tyrod Taylor got himself a nice contract extension this offseason, but that doesn't mean that the Bills will make the playoffs after missing them for the last 16 years. The Jags, meanwhile, are still waiting for Blake Bortles to develop, after he took the most sacks in the league for a second straight season -- his only two in the league.
Saints at Chargers, Week 4
If you're into fantasy football, this one might not be too bad, because Drew Brees and Philip Rivers can light it up with the best of 'em. But in terms of quality football, two teams that will struggle to reach the .500 mark this season facing off leaves little to be excited about.
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Jaguars at Titans, Week 8
We know all about Blake Bortles and how he's struggled in his first two seasons in Jacksonville, but unless Marcus Mariota develops more quickly than expected, division game or not, this could be a rough one as our only option on Thursday night.
Getty ImagesJim Rogash
Browns at Bengals, Week 7
The Bengals might be pretty good again this season, even though they've been one and done in the playoffs for the last five years. The Browns almost certainly won't be, however, so despite the rivalry aspect of this one, Cincinnati should comfortably cruise.
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Dolphins at Rams, Week 11
The hype of the Rams returning to Los Angeles should have worn off by now, and the reality that this year's L.A. squad isn't very good should have sufficiently set in. This will likely be an NFL contest between two bad teams, and that makes it unwatchable no matter where the game is played.
49ers at Bills, Week 6
It won't matter if Blaine Gabbert or Colin Kaepernick is starting at quarterback for the Niners at this point. San Francisco projects to be dismal either way, and West Coast teams don't historically fare well when traveling East to face an opponent, even one as underwhelming as the 2016 Bills.
Getty ImagesEzra Shaw
Falcons at Buccaneers, Week 9
Julio Jones led the league with 1,871 yards receiving last year, but the end result was a record of just 8-8 for the Falcons -- a clear disappointment after a 6-1 start. Tampa Bay, meanwhile, dropped its last four to end 2015 after a 6-6 start, so what we're saying is that we have zero confidence in either of these teams as we enter the 2016 season.
Getty ImagesScott Cunningham
Rams at Patriots, Week 13
The Rams should be confirmed to be trash at this point, while New England should be coming together as one of the most formidable teams in the AFC. Especially at home, the Patriots should roll the Rams in this one.
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49ers at Cardinals, Week 10
Arizona will, by all accounts, be competing for the NFC crown this season. A home game against what should be a dismal Niners team 10 weeks into the season should be a foregone conclusion.
Getty ImagesChristian Petersen
Rams at Seahawks, Week 15
A division game, sure, but one that the Seahawks will be hard-pressed to lose. Seattle and Arizona are far and away the favorites to take home the NFC West division title, while the Rams have nothing going for them other than returning to Los Angeles. Add in the fact that this is the only option for fans on Thursday night, and this could easily be one of the roughest games of the season.
Chargers at Browns, Week 16
Josh Gordon and the Browns might be cooking a bit by the end of the regular season, but what's more likely is that the Browns' dumpster fire burns as brightly as it ever has. The Chargers are expected to be almost as bad, so a Week 16 matchup between these two clubs seems like one that you should almost definitely be able to skip.
Getty ImagesScott Cunningham
Cardinals at Dolphins, Week 14
Will Ryan Tannehill be the answer for Miami this season? Maybe, but what's more likely is that the Cardinals continue to evolve as one of the NFC's top teams.
Getty ImagesMike Ehrmann
Rams at 49ers, Week 1
Thanks to the Rams being the subject of HBO's "Hard Knocks" (along with their return to Los Angeles), there will be plenty of interest around the team to start the season. But fans will quickly learn that L.A. might be among the league's worst, and an early-season matchup against an equally bad 49ers team might help hammer that point home.
Getty ImagesChristian Petersen
Seahawks at 49ers, Week 17
This has all the makings of being the worst game of the year. Seattle could easily have clinched its playoff position before the final week of the regular season, which would make this game meaningless for the Seahawks, and one where they would exclusively play their reserves. The Niners, meanwhile, will be lucky to win four games in 2016, so they might be completely demoralized by the time the ball is kicked off to begin Week 17.