How to Watch Pittsburgh vs. Louisville: Time, TV Channel, Live Stream – September 27, 2025

Updated Sep. 27, 2025 11:28 a.m. ET

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The Pittsburgh Panthers (2-1) will take on Chris Bell and the Louisville Cardinals (3-0) on Saturday at 12 p.m. ET. This game will be airing on ESPN2.

Keep up with college football all season on FOX Sports. Learn more about the Louisville Cardinals and the Pittsburgh Panthers.

How to Watch Louisville vs. Pittsburgh

When: Saturday, September 27, 2025 at 12 p.m. ET
Location: Acrisure Stadium in Pittsburgh, Pennsylvania
TV Channel: ESPN2
Live Box Score: FOX Sports

Louisville vs. Pittsburgh: Head to Head

In the past three meetings, Louisville owns a 2-1 record against Pittsburgh.
The Cardinals' record ATS is 2-1 in the last three times they have played the Panthers while the scoring has gone over the point total on one occasion.
Louisville has outpaced Pittsburgh 82 points to 57 in the past three games.

Louisville's 2025 Schedule

Date	Opponent	Score
8/30/2025	vs. Eastern Kentucky	W 51-17
9/5/2025	vs. James Madison	W 28-14
9/20/2025	vs. Bowling Green	W 40-17
9/27/2025	at Pittsburgh	-
10/4/2025	vs. Virginia	-
10/17/2025	at Miami (FL)	-
10/25/2025	vs. Boston College	-
11/1/2025	at Virginia Tech	-
11/8/2025	vs. California	-
11/14/2025	vs. Clemson	-
11/22/2025	at SMU	-
11/29/2025	vs. Kentucky	-

Louisville 2025 Stats & Insights

Defensively, Louisville has been a top-25 unit, ranking 15th-best by surrendering only 244.7 yards per game. The offense ranks 59th (415 yards per game).
On defense, Louisville has been a top-25 unit in terms of passing yards, ranking fourth-best by allowing just 114.7 passing yards per game. The Cardinals rank 44th on offense (259 passing yards per game).
On offense, the Cardinals rank 27th in the FBS with 39.7 points per game. Meanwhile, they rank 28th in points allowed (244.7 points allowed per contest).
On offense, the Cardinals rank 75th in the FBS with 156 rushing yards per game. Meanwhile, they rank 56th in rushing yards allowed per contest (130).
Louisville ranks 49th in third-down efficiency (44.1%) on offense and 42nd in third-down conversion rate allowed (32.6%) on defense this year.
The Cardinals own the 85th-ranked turnover margin in college football at -1, forcing four turnovers (75th in the FBS) while turning it over five times (74th in the FBS).

Louisville 2025 Key Players

Name	Position	Stats
Isaac Brown	RB	248 YDS / 3 TD / 82.7 YPG / 13.1 YPC 3 REC / 14 REC YDS / 0 REC TD / 14 REC YPG
Keyjuan Brown	RB	110 YDS / 3 TD / 36.7 YPG / 5 YPC 4 REC / 47 REC YDS / 0 REC TD / 23.5 REC YPG
Miller Moss	QB	690 YDS (66.3%) / 2 TD / 2 INT -25 RUSH YDS / 1 RUSH TD / -8.3 RUSH YPG
Caullin Lacy	WR	14 REC / 171 YDS / 0 TD / 57 YPG
Clev Lubin	DL	19 TKL / 2 TFL / 3.5 SACK
D'Angelo Hutchinson	DB	16 TKL / 1 TFL / 1 INT / 1 PD
Antonio Watts	LB	9 TKL / 1 TFL / 1 SACK / 1 INT
TJ Quinn	LB	16 TKL / 1 TFL / 1 SACK

Pittsburgh's 2025 Schedule

Date	Opponent	Score
8/30/2025	vs. Duquesne	W 61-9
9/6/2025	vs. Central Michigan	W 45-17
9/13/2025	at West Virginia	L 31-24
9/27/2025	vs. Louisville	-
10/4/2025	vs. Boston College	-
10/11/2025	at Florida State	-
10/18/2025	at Syracuse	-
10/25/2025	vs. North Carolina State	-
11/1/2025	at Stanford	-
11/15/2025	vs. Notre Dame	-
11/22/2025	at Georgia Tech	-
11/29/2025	vs. Miami (FL)	-

Pittsburgh 2025 Stats & Insights

From an offensive perspective, Pittsburgh is compiling 424.3 total yards per game (54th-ranked). It ranks 31st in the FBS defensively (286.3 total yards allowed per game).
Pittsburgh's pass offense has been dominant, piling up 315 passing yards per contest (18th-best) this season. On defense, it ranks 64th by allowing 202.7 passing yards per game.
The Panthers' offense has been dominant, piling up 43.3 points per game (17th-best) this season. On defense, they rank 44th by allowing 19 points per game.
The Panthers rank 19th-worst in rushing yards per game on offense (109.3), but at least they've been shutting down opposing offenses on defense, ranking 18th-best in rushing yards surrendered per contest (83.7).
Pittsburgh's third-down defense has been leading the way for the team, as it ranks 19th-best in the FBS with a 26.5% third-down conversion percentage allowed. In terms of offense, it is generating a 37.5% third-down rate, which ranks 91st.
After forcing three turnovers (96th in the FBS) and turning the ball over three times (30th in the FBS) this season, the Panthers sport the 60th-ranked turnover margin of 0.

Pittsburgh 2025 Key Players

Name	Position	Stats
Eli Holstein	QB	822 YDS (65.9%) / 9 TD / 3 INT 50 RUSH YDS / 1 RUSH TD / 16.7 RUSH YPG
Raphael Williams	WR	13 REC / 285 YDS / 3 TD / 95 YPG
Desmond Reid	RB	142 YDS / 1 TD / 47.3 YPG / 5.9 YPC 6 REC / 71 REC YDS / 0 REC TD / 23.7 REC YPG
Juelz Goff	RB	84 YDS / 2 TD / 28 YPG / 4 YPC 3 REC / 23 REC YDS / 0 REC TD / 11.5 REC YPG
Kyle Louis	LB	19 TKL / 4 TFL / 2 SACK / 1 INT
Rasheem Biles	LB	28 TKL / 2 TFL
Francis Brewu	DL	15 TKL / 1 TFL / 1 SACK
Cruce Brookins	DB	23 TKL / 0 TFL