College Football Top 25 Week 5 2025 Predictions, Betting Odds & TV Schedule

The Week 5 college football schedule includes 12 games with a ranked team on the field. Among those games is the No. 6 Oregon Ducks taking on the No. 3 Penn State Nittany Lions.

There is college football action this weekend, and we have you covered with the betting odds you need to get an edge.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season’s action.

Week 5 Betting Lines & Game Info

Virginia Cavaliers vs. No. 8 Florida State Seminoles

Odds & Prediction

• Spread: Seminoles (-7)
• Moneyline: Seminoles -265, Cavaliers +215
• Total: 60.5 points
• Prediction: Virginia 33, Florida State 30

How to Watch

• Game Date: Friday, Sept. 26
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Charlottesville, Virginia
• Box Score

Wake Forest Demon Deacons vs. No. 16 Georgia Tech Yellow Jackets

Odds & Prediction

• Spread: Yellow Jackets (-13.5)
• Moneyline: Yellow Jackets -549, Demon Deacons +410
• Total: 53.5 points
• Prediction: Wake Forest 26, Georgia Tech 20

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 12 p.m. ET
• TV Channel: ESPN
• Location: Winston-Salem, North Carolina
• Box Score

No. 18 Vanderbilt Commodores vs. Utah State Aggies

Odds & Prediction

• Spread: Commodores (-22.5)
• Moneyline: Commodores -2083, Aggies +1100
• Total: 57.5 points
• Prediction: Vanderbilt 52, Utah State 11

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 12:45 p.m. ET
• TV Channel: SEC Network
• Location: Nashville, Tennessee
• Box Score

No. 13 Ole Miss Rebels vs. No. 4 LSU Tigers

Odds & Prediction

• Spread: Rebels (-1.5)
• Moneyline: Rebels -125, Tigers +105
• Total: 58.5 points
• Prediction: Ole Miss 33, LSU 13

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 3:30 p.m. ET
• TV Channel: ABC
• Location: Oxford, Mississippi
• Box Score

Iowa Hawkeyes vs. No. 11 Indiana Hoosiers

Odds & Prediction

• Spread: Hoosiers (-8.5)
• Moneyline: Hoosiers -325, Hawkeyes +260
• Total: 47.5 points
• Prediction: Indiana 48, Iowa 6

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 3:30 p.m. ET
• TV Channel: Peacock
• Location: Iowa City, Iowa
• Box Score

No. 9 Texas A&M Aggies vs. Auburn Tigers

Odds & Prediction

• Spread: Aggies (-6.5)
• Moneyline: Aggies -258, Tigers +210
• Total: 51.5 points
• Prediction: Texas A&M 35, Auburn 24

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN
• Location: College Station, Texas
• Box Score

Washington Huskies vs. No. 1 Ohio State Buckeyes

Odds & Prediction

• Spread: Buckeyes (-8.5)
• Moneyline: Buckeyes -345, Huskies +275
• Total: 53.5 points
• Prediction: Washington 36, Ohio State 17

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 3:30 p.m. ET
• TV Channel: CBS
• Location: Seattle, Washington
• Box Score

Mississippi State Bulldogs vs. No. 15 Tennessee Volunteers

Odds & Prediction

• Spread: Volunteers (-7.5)
• Moneyline: Volunteers -305, Bulldogs +245
• Total: 63.5 points
• Prediction: Mississippi State 39, Tennessee 24

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 4:15 p.m. ET
• TV Channel: SEC Network
• Location: Starkville, Mississippi
• Box Score

No. 14 Iowa State Cyclones vs. Arizona Wildcats

Odds & Prediction

• Spread: Cyclones (-4.5)
• Moneyline: Cyclones -192, Wildcats +160
• Total: 48.5 points
• Prediction: Arizona 21, Iowa State 20

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Ames, Iowa
• Box Score

No. 3 Penn State Nittany Lions vs. No. 6 Oregon Ducks

Odds & Prediction

• Spread: Nittany Lions (-3.5)
• Moneyline: Nittany Lions -170, Ducks +142
• Total: 53.5 points
• Prediction: Oregon 34, Penn State 17

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 7:30 p.m. ET
• TV Channel: NBC
• Location: University Park, Pennsylvania
• Box Score

No. 20 Missouri Tigers vs. UMass Minutemen

Odds & Prediction

• Spread: Tigers (-44.5)
• Moneyline: Tigers , Minutemen
• Total: 57.5 points
• Prediction: Missouri 54, UMass 3

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 7:30 p.m. ET
• TV Channel: ESPNU
• Location: Columbia, Missouri
• Box Score

No. 5 Georgia Bulldogs vs. No. 17 Alabama Crimson Tide

Odds & Prediction

• Spread: Bulldogs (-2.5)
• Moneyline: Bulldogs -125, Crimson Tide +105
• Total: 53.5 points
• Prediction: Alabama 32, Georgia 31

How to Watch

• Game Date: Saturday, Sept. 27
• Game Time: 7:30 p.m. ET
• TV Channel: ABC
• Location: Athens, Georgia
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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