North Carolina vs. Charlotte Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 3:04 p.m. ET

FOX Sports

The Charlotte 49ers (0-1) are two-touchdown underdogs on Saturday, September 6, 2025 against the North Carolina Tar Heels (0-1). The over/under is 49.5.

The Tar Heels' most recent contest was versus the TCU Horned Frogs, and they lost by a score of 48-14. In their last game, the 49ers lost against the Appalachian State Mountaineers, 34-11.

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North Carolina vs. Charlotte Game Information & Odds

When: Saturday, September 6, 2025 at 7 p.m. ET
Location: Jerry Richardson Stadium in Charlotte, North Carolina
TV: ESPN+
Live Box Score on FOX Sports

North Carolina vs Charlotte Betting Information updated as of September 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
North Carolina	-14 (-110)	-595	+430	49.5	-110	-110

North Carolina vs. Charlotte Prediction

Pick ATS: Charlotte (+14)
Pick OU: Over (49.5)
Prediction: North Carolina 28, Charlotte 26

Predictions are made by the Data Skrive betting model.

Learn more about the North Carolina Tar Heels vs. the Charlotte 49ers game on FOX Sports!

North Carolina vs. Charlotte Betting Insights

Per the spread and over/under, the implied score for the matchup is Tar Heels 32, 49ers 18.
The Tar Heels have an 85.6% chance to win this game based on the moneyline's implied probability. The 49ers hold an 18.9% implied probability.
North Carolina has compiled a 0-1-0 record against the spread this season.
Charlotte has not won against the spread this year in one chances.

North Carolina vs. Charlotte: 2025 Stats Comparison

	North Carolina	Charlotte
Off. Points per Game (Rank)	14 (107)	11 (117)
Def. Points per Game (Rank)	48 (127)	34 (107)
Turnovers Allowed (Rank)	3 (119)	2 (100)
Turnovers Forced (Rank)	1 (51)	1 (51)

North Carolina 2025 Key Players

Name	Position	Stats
Caleb Hood	RB	31 YDS / 1 TD / 31 YPG / 3.1 YPC 1 REC / 15 REC YDS / 0 REC TD / 15 REC YPG
Jordan Shipp	WR	4 REC / 84 YDS / 0 TD / 84 YPG
Max Johnson	QB	103 YDS (81.8%) / 1 TD / 0 INT
Jake Johnson	TE	1 REC / 2 YDS / 1 TD / 2 YPG
Andrew Simpson	LB	11 TKL / 1 TFL
Kaleb Cost	DB	6 TKL / 0 TFL / 1 INT / 1 PD
Khmori House	LB	7 TKL / 1 TFL
Marcus Allen	DB	5 TKL / 0 TFL

Charlotte 2025 Key Players

Name	Position	Stats
Conner Harrell	QB	142 YDS (54.2%) / 1 TD / 1 INT 22 RUSH YDS / 0 RUSH TD / 22 RUSH YPG
E. Jai Mason	WR	2 REC / 29 YDS / 1 TD / 29 YPG
Justin Olson	WR	2 REC / 56 YDS / 0 TD / 56 YPG
CJ Stokes	RB	49 YDS / 0 TD / 49 YPG / 3.3 YPC
Ja'Qurious Conley	DB	6 TKL / 0 TFL
Mayco Williams	DL	3 TKL / 1 TFL / 1 SACK
Kadin Schmitz	LB	9 TKL / 0 TFL
Cary Grant	DB	6 TKL / 1 TFL