College Football Upsets from Week 1

In Week 1 of the 2025 college football campaign, we saw multiple upsets -- a complete list of which teams beat the odds is available below.

Check out the full college football schedule on FOX Sports.

Biggest College Football Upsets This Week

Presbyterian 15, Mercer 10

• Home Team: Mercer
• Spread Favorite: Mercer (-22.5)
• Moneyline: Mercer -1786, Presbyterian +1000
• O/U: Under (53.5)
• Box Score

Austin Peay 34, Middle Tennessee 14

• Home Team: Middle Tennessee
• Spread Favorite: Middle Tennessee (-15.5)
• Moneyline: Middle Tennessee -699, Austin Peay +500
• O/U: Under (53.5)
• Box Score

Central Michigan 16, San Jose State 14

• Home Team: San Jose State
• Spread Favorite: San Jose State (-14)
• Moneyline: San Jose State -549, Central Michigan +410
• O/U: Under (51.5)
• Box Score

Tarleton State 30, Army 27

• Home Team: Army
• Spread Favorite: Army (-14)
• Moneyline: Army -575, Tarleton State +425
• O/U: Over (47.5)
• Box Score

Florida State 31, Alabama 17

• Home Team: Florida State
• Spread Favorite: Alabama (-14)
• Moneyline: Alabama -599, Florida State +440
• O/U: Over (47.5)
• Box Score

Northwestern State 20, Alcorn State 10

• Home Team: Northwestern State
• Spread Favorite: Alcorn State (-10.5)
• Moneyline: Alcorn State -375, Northwestern State +295
• O/U: Under (48.5)
• Box Score

Rice 14, Louisiana 12

• Home Team: Louisiana
• Spread Favorite: Louisiana (-9.5)
• Moneyline: Louisiana -380, Rice +300
• O/U: Under (48.5)
• Box Score

Howard 10, Florida A&M 9

• Home Team: Florida A&M
• Spread Favorite: Florida A&M (-7.5)
• Moneyline: Florida A&M -265, Howard +215
• O/U: Under (48.5)
• Box Score

Gardner-Webb 52, Western Carolina 45

• Home Team: Western Carolina
• Spread Favorite: Western Carolina (-7)
• Moneyline: Western Carolina -238, Gardner-Webb +195
• O/U: Over (57.5)
• Box Score

St. Thomas 35, Lindenwood 13

• Home Team: St. Thomas
• Spread Favorite: Lindenwood (-6.5)
• Moneyline: Lindenwood -225, St. Thomas +185
• O/U: Under (49.5)
• Box Score

South Florida 34, Boise State 7

• Home Team: South Florida
• Spread Favorite: Boise State (-5.5)
• Moneyline: Boise State -205, South Florida +170
• O/U: Under (62.5)
• Box Score

West Georgia 34, Samford 3

• Home Team: Samford
• Spread Favorite: Samford (-5.5)
• Moneyline: Samford -225, West Georgia +185
• O/U: Under (55.5)
• Box Score

New Hampshire 27, North Carolina Central 10

• Home Team: North Carolina Central
• Spread Favorite: North Carolina Central (-4.5)
• Moneyline: North Carolina Central -180, New Hampshire +150
• O/U: Under (50.5)
• Box Score

LSU 17, Clemson 10

• Home Team: Clemson
• Spread Favorite: Clemson (-4.5)
• Moneyline: Clemson -205, LSU +170
• O/U: Under (55.5)
• Box Score

Marist 31, New Haven 14

• Home Team: Marist
• Spread Favorite: New Haven (-3)
• Moneyline: New Haven -170, Marist +142
• O/U: Under (48.5)
• Box Score

Miami (FL) 27, Notre Dame 24

• Home Team: Miami (FL)
• Spread Favorite: Notre Dame (-3)
• Moneyline: Notre Dame -148, Miami (FL) +124
• O/U: Over (50.5)
• Box Score

Fresno State 42, Georgia Southern 14

• Home Team: Fresno State
• Spread Favorite: Georgia Southern (-1.5)
• Moneyline: Georgia Southern -120, Fresno State +100
• O/U: Over (49.5)
• Box Score

Prairie View A&M 22, Texas Southern 21

• Home Team: Texas Southern
• Spread Favorite: Texas Southern (-1.5)
• Moneyline: Texas Southern -118, Prairie View A&M -102
• O/U: Under (48.5)
• Box Score

Cal Poly 41, San Diego 17

• Home Team: San Diego
• Spread Favorite: San Diego (-0)
• Moneyline: San Diego -110, Cal Poly -110
• O/U: Over (50.5)
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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