Houston vs. Oregon State Prediction, Odds, Picks - September 26, 2025

Updated Sep. 26, 2025 9:04 p.m. ET

Data Skrive

The Oregon State Beavers (0-4) are double-digit, 12.5-point underdogs heading into their matchup on Friday, September 26, 2025 against the Houston Cougars (3-0). The contest has an over/under of 47.5 points.

The Cougars beat the Colorado Buffaloes, 36-20, in their last contest. The Beavers' most recent contest was against the Oregon Ducks, and they lost by a score of 41-7.

Keep up with college football all season on FOX Sports.

Houston vs. Oregon State Game Information & Odds

When: Friday, September 26, 2025 at 10:30 p.m. ET
Location: Reser Stadium in Corvallis, Oregon
TV: ESPN
Live Box Score on FOX Sports

Houston vs Oregon State Betting Information updated as of September 26, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Houston	-12.5 (-112)	-503	+377	47.5	-111	-108

Houston vs. Oregon State Prediction

Pick ATS: Houston (-12.5)
Pick OU: Over (47.5)
Prediction: Houston 40, Oregon State 12

Predictions are made by the Data Skrive betting model.

Learn more about the Houston Cougars vs. the Oregon State Beavers game on FOX Sports!

Houston vs. Oregon State Betting Insights

Per the spread and over/under, the implied score for the matchup is Cougars 30, Beavers 18.
The Cougars have an 83.4% chance to claim victory in this contest per the moneyline's implied probability. The Beavers have a 21.0% implied probability.
Houston is 3-0-0 ATS this season.
Oregon State has covered once in four chances against the spread this season.

Houston vs. Oregon State: 2025 Stats Comparison

	Houston	Oregon State
Off. Points per Game (Rank)	32.7 (83)	15.8 (122)
Def. Points per Game (Rank)	9.7 (6)	39 (131)
Turnovers Allowed (Rank)	0 (1)	7 (117)
Turnovers Forced (Rank)	6 (26)	3 (93)

Houston 2025 Key Players

Name	Position	Stats
Conner Weigman	QB	569 YDS (64.3%) / 4 TD / 0 INT 145 RUSH YDS / 3 RUSH TD / 48.3 RUSH YPG
Dean Connors	RB	271 YDS / 3 TD / 90.3 YPG / 5.4 YPC
Stephon Johnson Jr.	WR	6 REC / 191 YDS / 1 TD / 63.7 YPG
Tanner Koziol	TE	17 REC / 148 YDS / 1 TD / 49.3 YPG
Eddie Walls III	DL	6 TKL / 2 TFL / 2 SACK
Khalil Laufau	DL	7 TKL / 1 TFL / 1 SACK
Corey Platt Jr.	LB	4 TKL / 2 TFL / 2 SACK
Brandon Mack	LB	4 TKL / 0 TFL / 1.5 SACK

Oregon State 2025 Key Players

Name	Position	Stats
Maalik Murphy	QB	964 YDS (57.3%) / 6 TD / 5 INT -19 RUSH YDS / 1 RUSH TD / -4.8 RUSH YPG
Anthony Hankerson	RB	228 YDS / 2 TD / 57 YPG / 3.5 YPC
Trent Walker	WR	23 REC / 302 YDS / 0 TD / 75.5 YPG
Tastean Reddicks	WR	17 REC / 240 YDS / 0 TD / 60 YPG
Skyler Thomas	DB	22 TKL / 0 TFL / 1 INT / 1 PD
Dexter Foster	LB	23 TKL / 1 TFL
Jaheim Patterson	DB	17 TKL / 0 TFL
Sailasa Vadrawale	DB	14 TKL / 1 TFL