White Sox pitcher Jake Peavy has been pushed back a day and will start Thursday's series opener against the Tampa Bay Rays.
Chicago manager Robin Ventura will start left-hander Hector Santiago in Wednesday's series finale against the Cleveland Indians.
Santiago is 3-1 with a 3.45 ERA in two starts and 38 relief appearances this season.
Ventura said Tuesday morning that lefty Chris Sale would get an extra day of rest, but the team announced after a 4-3 loss to the Indians on Tuesday that Sale would start Saturday on regular rest instead.
Righty Gavin Floyd was moved up to Friday, replacing Jose Quintana, who pitched two-thirds of an inning of relief Tuesday, throwing four pitches.
Chicago began Tuesday with a one-game lead over Detroit in the AL Central.