Louisville vs. Pittsburgh Prediction, Odds, Picks - November 23, 2024

Updated Nov. 23, 2024 3:04 p.m. ET

FOX Sports

Two of the nation's strongest passing offenses square off when the Louisville Cardinals (6-4) bring college football's 15th-ranked passing offense into a matchup with the Pittsburgh Panthers (7-3), who have the No. 16 passing offense, on Saturday, November 23, 2024. The Cardinals are 7.5-point favorites. A 57.5-point over/under is set for the game.

The Cardinals' last contest was versus the Stanford Cardinal, and they lost by a score of 38-35. The Panthers lost versus the Clemson Tigers in their most recent game, 24-20.

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Louisville vs. Pittsburgh Game Information & Odds

When: Saturday, November 23, 2024 at 4 p.m. ET
Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
TV: ESPN2
Live Box Score on FOX Sports

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Louisville vs Pittsburgh Betting Information updated as of November 23, 2024, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-7.5 (-105)	-273	+221	57.5	-110	-110

Louisville vs. Pittsburgh Prediction

Pick ATS: Louisville (-7.5)
Pick OU: Over (57.5)
Prediction: Louisville 34, Pittsburgh 25

Predictions are made by the Data Skrive betting model.

Learn more about the Louisville Cardinals vs. the Pittsburgh Panthers game on FOX Sports!

Louisville vs. Pittsburgh Betting Insights

Per the spread and over/under, the implied score for the game is Cardinals 32, Panthers 25.
The Cardinals have a 73.2% chance to claim victory in this meeting based on the moneyline's implied probability. The Panthers hold a 31.2% implied probability.
Louisville has compiled a 3-6-0 ATS record so far this year.
Pittsburgh is 7-3-0 ATS this season.

Louisville vs. Pittsburgh: Head-to-Head

In their past two matchups, Pittsburgh holds a split 1-1 record against Louisville.
The two teams have gone over the total on one occasion while sharing an even 1-1 record in their games against the spread.
In their last two head-to-head matchups, Pittsburgh has compiled 48 points against Louisville, while surrendering only 45 points.

Louisville vs. Pittsburgh: 2024 Stats Comparison

	Louisville	Pittsburgh
Off. Points per Game (Rank)	36.1 (19)	35 (26)
Def. Points per Game (Rank)	25.6 (72)	25 (67)
Turnovers Allowed (Rank)	10 (26)	12 (43)
Turnovers Forced (Rank)	8 (127)	16 (39)

Louisville 2024 Key Players

Name	Position	Stats
Tyler Shough	QB	2,774 YDS (63.6%) / 21 TD / 6 INT 14 RUSH YDS / 1 RUSH TD / 1.6 RUSH YPG
Ja'Corey Brooks	WR	57 REC / 945 YDS / 8 TD / 94.5 YPG
Isaac Brown	RB	803 YDS / 7 TD / 80.3 YPG / 7.4 YPC 26 REC / 131 REC YDS / 1 REC TD / 14.6 REC YPG
Duke Watson	RB	341 YDS / 5 TD / 37.9 YPG / 8.5 YPC 2 REC / 35 REC YDS / 1 REC TD / 7 REC YPG
Stanquan Clark	LB	55 TKL / 4 TFL
TJ Quinn	LB	64 TKL / 1 TFL / 1 SACK
Tamarion McDonald	DB	45 TKL / 3 TFL / 2 SACK
Ashton Gillotte	DL	33 TKL / 5 TFL / 2.5 SACK

Pittsburgh 2024 Key Players

Name	Position	Stats
Eli Holstein	QB	2,177 YDS (62.1%) / 17 TD / 6 INT 323 RUSH YDS / 3 RUSH TD / 35.9 RUSH YPG
Desmond Reid	RB	738 YDS / 4 TD / 73.8 YPG / 5.6 YPC 43 REC / 536 REC YDS / 4 REC TD / 59.6 REC YPG
Konata Mumpfield	WR	40 REC / 618 YDS / 3 TD / 61.8 YPG
Raphael Williams	WR	31 REC / 363 YDS / 5 TD / 36.3 YPG
Kyle Louis	LB	71 TKL / 12 TFL / 7 SACK / 4 INT
Rasheem Biles	LB	60 TKL / 12 TFL / 4 SACK / 1 INT
Brandon George	LB	58 TKL / 2 TFL / 2 SACK / 1 INT
Donovan McMillon	DB	69 TKL / 0 TFL / 1 INT / 1 PD