Florida vs. South Florida Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 3:04 p.m. ET

FOX Sports

The No. 13 Florida Gators (1-0) are big 17.5-point favorites on Saturday, September 6, 2025 against the South Florida Bulls (1-0). The over/under for the game is set at 57.

The Gators won versus the LIU Sharks in their last game, 55-0. The Bulls' last contest was versus the Boise State Broncos, and they won by a score of 34-7.

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Florida vs. South Florida Game Information & Odds

When: Saturday, September 6, 2025 at 4:15 p.m. ET
Location: Ben Hill Griffin Stadium in Gainesville, Florida
TV: SEC Network
Live Box Score on FOX Sports

Florida vs South Florida Betting Information updated as of September 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Florida	-17.5 (-120)	-917	+603	57	-110	-110

Florida vs. South Florida Prediction

Pick ATS: Florida (-17.5)
Pick OU: Over (57)
Prediction: Florida 40, South Florida 17

Predictions are made by the Data Skrive betting model.

Learn more about the Florida Gators vs. the South Florida Bulls game on FOX Sports!

Florida vs. South Florida Betting Insights

Per the spread and over/under, the implied score for the game is Gators 37, Bulls 20.
The Gators have a 90.2% chance to win this game based on the moneyline's implied probability. The Bulls hold a 14.2% implied probability.
Florida has won all one of its games against the spread this season.
South Florida has won one game against the spread this season.

Florida vs. South Florida: Head-to-Head

In their past two head-to-head matchups, Florida has taken down South Florida two times.
In those contests against Florida, the Bulls have covered two times while outscoring the total both times.
In their last two head-to-head matchups, Florida has compiled 73 points against South Florida, while giving up only 48 points.

Florida vs. South Florida: 2025 Stats Comparison

	Florida	South Florida
Off. Points per Game (Rank)	55 (19)	34 (55)
Def. Points per Game (Rank)	0 (1)	7 (20)
Turnovers Allowed (Rank)	0 (1)	0 (1)
Turnovers Forced (Rank)	2 (22)	3 (8)

Florida 2025 Key Players

Name	Position	Stats
DJ Lagway	QB	120 YDS (83.3%) / 3 TD / 0 INT
Jadan Baugh	RB	104 YDS / 1 TD / 104 YPG / 11.6 YPC
Tramell Jones Jr.	QB	131 YDS (66.7%) / 2 TD / 0 INT 14 RUSH YDS / 0 RUSH TD / 14 RUSH YPG
Hayden Hansen	TE	3 REC / 27 YDS / 1 TD / 27 YPG
Bryce Thornton	DB	1 TKL / 0 TFL
Jaden Robinson	LB	2 TKL / 1 TFL
Myles Graham	LB	5 TKL / 1 TFL
Kamran James	DL	4 TKL / 1 TFL

South Florida 2025 Key Players

Name	Position	Stats
Byrum Brown	QB	210 YDS (66.7%) / 0 TD / 0 INT 43 RUSH YDS / 2 RUSH TD / 43 RUSH YPG
Keshaun Singleton	WR	5 REC / 93 YDS / 1 TD / 93 YPG
Cartevious Norton	RB	15 YDS / 1 TD / 15 YPG / 2.1 YPC 1 REC / 24 REC YDS / 0 REC TD / 24 REC YPG
Chas Nimrod	WR	3 REC / 96 YDS / 0 TD / 96 YPG
Jhalyn Shuler	LB	14 TKL / 1 TFL
Jonas Duclona	DB	6 TKL / 1 TFL
De'Shawn Rucker	DB	11 TKL / 0 TFL
Mac Harris	LB	8 TKL / 0 TFL