East Carolina vs. Charlotte Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 3:04 p.m. ET

FOX Sports

The Charlotte 49ers (1-7) are 28.5-point underdogs in a road AAC matchup with the East Carolina Pirates (5-3) on Saturday, November 8, 2025 at Bagwell Field at Dowdy-Ficklen Stadium. The contest has an over/under of 56.5 points.

Last time around, the Pirates defeated the Temple Owls, with 45-14 being the final score. Against the North Texas Mean Green in their last game, the 49ers lost 54-20.

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East Carolina vs. Charlotte Game Information & Odds

When: Saturday, November 8, 2025 at 3 p.m. ET
Location: Bagwell Field at Dowdy-Ficklen Stadium in Greenville, North Carolina
TV: ESPN+
Live Box Score on FOX Sports

East Carolina vs Charlotte Betting Information updated as of November 8, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
East Carolina	-28.5 (-109)	-5263	+1670	56.5	-109	-111

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East Carolina vs. Charlotte Prediction

Pick ATS: East Carolina (-28.5)
Pick OU: Under (56.5)
Prediction: East Carolina 45, Charlotte 5

Predictions are made by the Data Skrive betting model.

Learn more about the East Carolina Pirates vs. the Charlotte 49ers game on FOX Sports!

East Carolina vs. Charlotte Betting Insights

Per the spread and over/under, the implied score for the matchup is Pirates 42, 49ers 14.
The Pirates have a 98.1% chance to claim victory in this game based on the moneyline's implied probability. The 49ers hold a 5.6% implied probability.
East Carolina is 5-3-0 ATS this season.
Charlotte has won just two games against the spread this season.

East Carolina vs. Charlotte: Head-to-Head

Over their last two meetings, Charlotte has collected two wins versus East Carolina.
The 49ers have a 2-0 record ATS in those games, while the two teams have gone over the point total on one occasion.
Over their last two head-to-head matchups, Charlotte has scored 65 points, while East Carolina has posted 31.

East Carolina vs. Charlotte: 2025 Stats Comparison

	East Carolina	Charlotte
Off. Points per Game (Rank)	32.1 (60)	17.5 (130)
Def. Points per Game (Rank)	16.8 (12)	37.3 (127)
Turnovers Allowed (Rank)	7 (14)	16 (122)
Turnovers Forced (Rank)	11 (56)	8 (98)

East Carolina 2025 Key Players

Name	Position	Stats
Katin Houser	QB	2,245 YDS (66.9%) / 12 TD / 5 INT 85 RUSH YDS / 4 RUSH TD / 10.6 RUSH YPG
Anthony Smith	WR	36 REC / 614 YDS / 3 TD / 76.8 YPG
London Montgomery	RB	449 YDS / 4 TD / 56.1 YPG / 5 YPC
Yannick Smith	WR	35 REC / 474 YDS / 4 TD / 59.3 YPG
Ja'Marley Riddle	DB	36 TKL / 2 TFL / 2 INT / 2 PD
Jasiyah Robinson	DL	15 TKL / 3 TFL / 3.5 SACK
Samuel Dankah	DL	30 TKL / 3 TFL / 1.5 SACK
Preston Carr	DL	16 TKL / 2 TFL / 2 SACK

Charlotte 2025 Key Players

Name	Position	Stats
Javen Nicholas	WR	41 REC / 541 YDS / 3 TD / 67.6 YPG
Conner Harrell	QB	737 YDS (66.7%) / 4 TD / 2 INT 67 RUSH YDS / 2 RUSH TD / 16.8 RUSH YPG
E. Jai Mason	WR	23 REC / 332 YDS / 4 TD / 55.3 YPG
Grayson Loftis	QB	766 YDS (50.4%) / 5 TD / 4 INT
Reid Williford	LB	51 TKL / 4 TFL / 4 SACK
Kadin Schmitz	LB	47 TKL / 0 TFL / 1 INT / 1 PD
Shay Taylor	LB	39 TKL / 3 TFL / 1.5 SACK
Ja'Qurious Conley	DB	33 TKL / 0 TFL / 1 INT / 1 PD