Clemson vs. Penn State Prediction, Odds, Picks - December 27, 2025

Published Dec. 24, 2025 3:04 p.m. ET

Data Skrive

The Pinstripe Bowl features a battle between the Penn State Nittany Lions (who are 3-point underdogs) and the Clemson Tigers on December 27, 2025 at 12 p.m. ET on ABC. A total of 48.5 points has been set for this game.

Last time out, the Tigers defeated the South Carolina Gamecocks, with 28-14 being the final score. Last time around, the Nittany Lions defeated the Rutgers Scarlet Knights, with 40-36 being the final score.

Keep up with college football all season on FOX Sports.

Clemson vs. Penn State Game Information & Odds

When: Saturday, December 27, 2025 at 12 p.m. ET
Location: Yankee Stadium in The Bronx, New York
TV: ABC
Streaming: FOX One + ESPN Bundle

Clemson vs Penn State Betting Information updated as of December 24, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Clemson	-3 (-110)	-162	+137	48.5	-110	-110

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Clemson vs. Penn State Prediction

Pick ATS: Penn State (+3)
Pick OU: Over (48.5)
Prediction: Penn State 28, Clemson 23

Predictions are made by the Data Skrive betting model.

Learn more about the Clemson Tigers vs. the Penn State Nittany Lions game on FOX Sports!

Clemson vs. Penn State Betting Insights

Per the spread and over/under, the implied score for the matchup is Tigers 26, Nittany Lions 23.
The Tigers have a 61.8% chance to win this game per the moneyline's implied probability. The Nittany Lions have a 42.2% implied probability.
Clemson has won five games against the spread this season, while failing to cover seven times.
Penn State has put together a 4-8-0 ATS record so far this year.

Clemson vs. Penn State: 2025 Stats Comparison

	Clemson	Penn State
Off. Points per Game (Rank)	28.7 (64)	31.8 (44)
Def. Points per Game (Rank)	20.4 (24)	21.4 (33)
Turnovers Allowed (Rank)	15 (59)	10 (9)
Turnovers Forced (Rank)	17 (50)	13 (95)

Clemson 2025 Key Players

Name	Position	Stats
Cade Klubnik	QB	2,750 YDS (66.6%) / 16 TD / 6 INT 107 RUSH YDS / 4 RUSH TD / 9.7 RUSH YPG
Adam Randall	RB	779 YDS / 9 TD / 64.9 YPG / 5 YPC 31 REC / 246 REC YDS / 3 REC TD / 22.4 REC YPG
Antonio Williams	WR	55 REC / 604 YDS / 4 TD / 60.4 YPG
T.J. Moore	WR	46 REC / 754 YDS / 4 TD / 62.8 YPG
Sammy Brown	LB	83 TKL / 9 TFL / 5 SACK / 1 INT
Avieon Terrell	DB	45 TKL / 3 TFL / 3 SACK
Will Heldt	DL	39 TKL / 11 TFL / 6.5 SACK
Wade Woodaz	LB	67 TKL / 6 TFL / 0.5 SACK

Penn State 2025 Key Players

Name	Position	Stats
Kaytron Allen	RB	1,303 YDS / 15 TD / 108.6 YPG / 6.2 YPC
Nicholas Singleton	RB	549 YDS / 13 TD / 45.8 YPG / 4.5 YPC 24 REC / 219 REC YDS / 1 REC TD / 18.3 REC YPG
Drew Allar	QB	1,100 YDS (64.8%) / 8 TD / 3 INT 172 RUSH YDS / 1 RUSH TD / 28.7 RUSH YPG
Devonte Ross	WR	28 REC / 417 YDS / 5 TD / 34.8 YPG
Amare Campbell	LB	97 TKL / 8 TFL / 3 SACK
Zakee Wheatley	DB	75 TKL / 2 TFL / 1 INT / 1 PD
Dani Dennis-Sutton	DL	37 TKL / 8 TFL / 6.5 SACK
Dominic DeLuca	LB	59 TKL / 5 TFL / 2 SACK