Chiefs vs. Chargers 2025 Prediction, Odds, Picks - Sep 5

The Kansas City Chiefs (0-0) will travel to São Paulo, Brazil to square off gainst the Los Angeles Chargers (0-0) at Corinthians Arena on Friday, September 5, 2025. The Chiefs are favorites in this one, with the spread sitting at 3 points. The over/under for this one is set at 47.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Matt Hasselbeck talks Dak Prescott, A.J. Brown's lack of targets, Joe Burrow's early season struggles | FULL INTERVIEW | The Herd

Matt Hasselbeck joins Colin Cowherd to break down Dak Prescott's strong performance against the Philadelphia Eagles despite the loss, A.J. Brown continuing to not receive many targets (career-low 1 target vs. Dallas Cowboys) and why Joe Burrow struggles in September. He then predicts Los Angeles Chargers vs. Kansas City Chiefs in Brazil and shares his expectations for Micah Parsons against the Detroit Lions. Hasselbeck then explains why he is optimistic for the Seattle Seahawks this season and in Week 1 against the San Francisco 49ers.

Chiefs vs. Chargers Odds & Betting Lines

Chiefs vs. Chargers Prediction & Pick

• Pick ATS: Chargers (+3)
  
• Pick OU: Under (47.5)
  
• Prediction: Chiefs 21 - Chargers 20

How to Watch Kansas City vs. Los Angeles

• Game date: Friday, September 5, 2025
• Time: 8 p.m. ET
• Venue: Corinthians Arena
• Location: São Paulo, Brazil
• TV: YouTube
• Live Boxscore: FOX Sports

Chiefs vs. Chargers Recent Matchups

• Over their last five meetings, Kansas City has totaled five wins versus Los Angeles.
• Los Angeles has been outpaced by 27 points in its last five tilts versus Kansas City.

Kansas City Betting Info

• Kansas City won seven games against the spread last season, failing to cover 10 times.
• The Chiefs had an ATS record of 5-8 as 3-point favorites or greater last season.
• Kansas City and its opponent combined to hit the over in seven of 17 contests last season.
• The Chiefs won all 14 of the games they were favored on the moneyline last season.
• Kansas City won all 12 games it played as a moneyline favorite with odds of -166 or shorter.
• The implied moneyline probability in this matchup gives the Chiefs a 62.4% chance to win.

Chiefs Stats (2024)

Kansas City's Key Players

Offense

• Over the course of 16 games played last year, Patrick Mahomes racked up 3,928 passing yards (seventh-best in the NFL), while throwing 26 touchdowns (ninth in the NFL) against 11 interceptions and completing 67.5% of his passes.
• Mahomes also rushed for two touchdowns and 307 yards.
• Kareem Hunt had 728 rushing yards and seven rushing touchdowns, while averaging 56 yards per game and 3.6 per attempt (43rd in the NFL).
• Hunt also picked up 176 receiving yards (13.5 per game) on 23 catches (1.8 per game). He was targeted 32 times and is still seeking his first receiving touchdown.
• Xavier Worthy registered 638 receiving yards and six touchdowns on 59 receptions while being targeted 98 times last season.
• Travis Kelce had 97 catches for 823 yards and three receiving touchdowns. He averaged 6.1 yards per game over 16 games and was targeted 133 times.

Defense

• Nick Bolton's 2024 effort included 106 tackles, 11 TFL, three sacks, and one interception in 16 games.
• Drue Tranquill registered two sacks in addition to his four TFL and 94 tackles in 16 games.
• Chamarri Conner recorded one sack as well as four TFL, 70 tackles, and two interceptions in the 2024 campaign.
• George Karlaftis III's season stats include 35 tackles, nine TFL, and eight sacks over 16 games.

Los Angeles Betting Info

• Los Angeles won 13 games against the spread last year, failing to cover four times.
• The Chargers won twice ATS (2-2) as underdogs of 3 points or greater last season.
• In Los Angeles games last season, combined scoring went over the point total eight times.
• Last season, the Chargers were listed as the underdog in four games and failed to win any of those contests.
• Last season, Los Angeles was at least a +140 underdog on the moneyline two times, losing each of those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Chargers have a 41.7% chance to win.

Chargers Stats (2024)

Los Angeles' Key Players

Offense

• In 17 games last year, Justin Herbert racked up 3,870 passing yards (ninth-best in NFL), with 23 TD passes and three INTs, connecting on 65.9% of his passes.
• Herbert also rushed for two TDs and 306 yards.
• Najee Harris scored six rushing TDs, accumulating 1,043 rushing yards (4 per carry and 61.4 per game).
• Harris added 36 catches (2.1 per game) for 283 yards (16.6 per game), without a receiving touchdown. He was targeted 48 times.
• In 16 games last year, Ladd McConkey had 82 catches (5.1 per game on seven targets per game) for 1,149 yards (10th in the NFL) and seven TDs.
• Quentin Johnston had 711 yards receiving and eight TDs via 55 catches on 91 targets.

Defense

• Daiyan Henley had one sack to go along with seven TFL, 142 tackles, and one interception in his 16 games in 2024.
• Derwin James put up one interception on top of 93 tackles, 10 TFL, 5.5 sacks, and seven passes defended.
• Tuli Tuipulotu posted 8.5 sacks in addition to his 11 TFL and 38 tackles.
• Khalil Mack totaled six sacks plus six TFL and 39 tackles in 15 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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