49ers vs. Cardinals Prediction, Odds, Picks - Oct 1

Published Sep. 27, 2023 7:04 p.m. ET

Data Skrive

The San Francisco 49ers (3-0) are big favorites, expected to win by two touchdowns or more (currently -14) over the Arizona Cardinals (1-2). The 49ers have taken three games in a row. The predicted point total for the matchup is 44.

49ers vs. Cardinals Odds & Betting Lines

49ers vs Cardinals Betting Information updated as of September 27, 2023, 2:33 PM ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-14	-108	-112	44	-112	-108

49ers vs. Cardinals Prediction & Pick

Pick ATS: Arizona (+14)
Pick OU: Over (44)
Prediction: San Francisco 29 - Arizona 16

How to Watch San Francisco vs. Arizona

Game Date: Sunday, October 1, 2023
Time: 4:25 PM ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: Watch on FOX

49ers vs. Cardinals Recent Matchups

In their last five head-to-head contests, San Francisco has beaten Arizona four times.
Arizona has been outpaced by 63 points in its last five tilts versus San Francisco.

San Francisco Betting Info

San Francisco has two wins versus the spread in three games this year.
San Francisco's games this year have gone over the point total one time in three opportunities (33.3%).
The 49ers have not yet lost a game they played as the moneyline favorite, going 3-0 in those matchups this season.
San Francisco has yet to play a game with moneyline odds of -950 or shorter.
Looking at this contest's moneyline, the 49ers' implied win probability is 90.5%.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	236.3 (709)	10
Rush yards	162.7 (488)	3
Points scored	30 (90)	3
Pass yards against	205.3 (616)	14
Rush yards against	53 (159)	3
Points allowed	14 (42)	5

San Francisco's Key Players

Offense

On the ground, Christian McCaffrey averages 5.9 yards per attempt (sixth in the NFL) and 117.7 yards per game for 353 total rushing yards (first in the NFL). He has scored three rushing touchdowns this season.
McCaffrey has 13 targets, 11 catches, 70 receiving yards and zero TDs through the air.
Brock Purdy has 736 passing yards (10th in the NFL), four touchdowns and zero interceptions this year. He has completed 67% of his attempts, averaging 245.3 yards per game and 8.1 per attempt.
He's rushed for 24 yards (fourth on the 49ers) and added one touchdown on the ground, while averaging 8 rushing yards per game.
In the passing game, Deebo Samuel, has contributed with 247 receiving yards and one touchdown after catching 17 balls on 28 targets. Per game, he's averaging 82.3 yards and 5.7 receptions in three games.
Brandon Aiyuk averages 5.5 receptions and 86 yards per game, and has 172 total receiving yards and 11 catches. He's gotten 14 total targets, and has caught two touchdown passes (sixth in the NFL).

Defense

Over on defense, Fred Warner has 23 tackles, two TFL, one sack, and two passes defended in 2023.
Deommodore Lenoir has 25 tackles and one interception this season. He leads the 49ers in tackles.
Charvarius Ward has put up one interception (ninth in the NFL) and has added 17 tackles and four passes defended.
This season, Dre Greenlaw has 22 tackles and one TFL. He's third on the 49ers in tackles.

Arizona Betting Info

Arizona has covered the spread in each of its three games with a set spread.
Arizona games have gone over the total twice this season.
This season, the Cardinals have won one out of the three games in which they've been the underdog.
Arizona has not entered a game this season as a bigger underdog on the moneyline than the +625 odds on them winning this game.
The implied probability of a win by the Cardinals based on the moneyline is 13.8%.

Cardinals Stats

Stat	Average (Total)	Rank
Pass yards	173.3 (520)	27
Rush yards	156.3 (469)	6
Points scored	24 (72)	12
Pass yards against	233 (699)	21
Rush yards against	134.7 (404)	26
Points allowed	22.3 (67)	16

Arizona's Key Players

Offense

Joshua Dobbs has passed for 549 yards this year, with two touchdowns and zero interceptions. He is completing 72% of his attempts while averaging 183 yards per game and 6.7 per attempt.
He's added 93 yards on the ground (second on the Cardinals), while scoring one rushing touchdown. He's averaging 31 yards per game and 7.8 per attempt.
Dobbs has 549 passing yards, two touchdowns and zero interceptions. His completion percentage is 72% and he averages 183 yards per game and 6.7 per attempt.
He has tacked on 93 rushing yards (second on the Cardinals), with one touchdown on the ground (averaging 31 yards per game and 7.8 per carry).
James Conner has rushed for two touchdowns this year, and has totaled 266 rushing yards (88.7 per game and 5.2 per carry).
Marquise Brown has 143 receiving yards and two touchdowns (sixth in the NFL) from 14 receptions after receiving 22 targets.

Defense

Kyzir White has put up one sack (fourth on the Cardinals) to go with three TFL, 30 tackles, and one interception over three games in 2023.
Dennis Gardeck's stat sheet includes 10 tackles, four TFL, and three sacks.
Victor Dimukeje has 2.5 sacks (second on the Cardinals) in addition to his two TFL and seven tackles.
Jalen Thompson has totaled one TFL, 20 tackles, and one interception through three games.