Twins vs. Astros Prediction, Odds, Picks - April 5

Bailey Ober will aim to shut down Yordan Alvarez and company when the Minnesota Twins take on the Houston Astros on Saturday at 2:10 p.m. ET, at Target Field. The favored Twins have -129 moneyline odds to win against the underdog Astros, who are listed at +109. Minnesota (-1.5) is the favorite on the run line. A 7.5-run over/under is listed for the game.

Check out everything you need to know from a betting perspective on the Twins-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Twins Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Minnesota Twins.

Twins vs. Astros Game Information & Odds

• When: Saturday, April 5, 2025 at 2:10 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and SCHN

Twins vs. Astros Prediction

• Score Prediction: Astros 7, Twins 6
• Total Prediction: Over 7.5 runs
• Win Probabilities: Twins 56%, Astros 44%

Twins vs. Astros Betting Insights

• This season, the Twins have won two out of the seven games in which they've been favored.
• This season Minnesota has won two of its four games when favored by at least -129 on the moneyline.
• The oddsmakers' moneyline implies a 56.3% chance of a victory for the Twins.
• The Astros have split the two games they've played as underdogs this season.
• Houston has been listed as an underdog of +109 or more on two occasions this season and split those games.
• The Astros have an implied victory probability of 47.8% according to the moneyline set for this matchup.

Twins Player Insights

• Harrison Bader is the Twins best power option, launching three home runs this season in addition to collecting eight RBI, both team highs.
• Willi Castro is hitting .261 to lead his team.
• Castro ranks 66th in homers and 100th in RBI in the majors.
• Byron Buxton is hitting .240 with a double, a home run and a walk.
• Buxton will look to build on his three-game hitting in this game. In his last five games he is hitting .353 with a double, a home run, a walk and three RBI.
• Ty France has a double and a walk while hitting .192.

Twins Team Props

Astros Player Insights

• Jeremy Pena has racked up a team-high two home runs.
• Among all batters in the majors, Pena ranks 29th in home runs and 152nd in RBI.
• Jose Altuve's .321 batting average paces his team.
• Altuve is 66th overall in home runs and 207th in RBI this season.
• Brendan Rodgers is hitting .313 with a double and two walks.
• Isaac Paredes is hitting .130 with a double and five walks.

Astros Team Props

Astros vs. Twins Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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