Guardians vs. White Sox Prediction, Odds, Picks - September 13

Jose Ramirez and the Cleveland Guardians will look to out-hit Kyle Teel and the Chicago White Sox at Progressive Field on Saturday at 6:10 p.m. ET. The Guardians are favored in this one, at -171, while the underdog White Sox have +144 odds to upset. Cleveland (-1.5) is the favorite on the run line. A 7.5-run total has been set for this matchup.

Take a look at everything you need to know from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. White Sox Game Information & Odds

• When: Saturday, September 13, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and CHSN

Guardians vs. White Sox Prediction

• Score Prediction: Guardians 4, White Sox 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Guardians 56%, White Sox 44%

Guardians vs. White Sox Betting Insights

• This season, the Guardians have been favored 62 times and won 38, or 61.3%, of those games.
• Cleveland has a record of 6-1 when favored by -171 or more by oddsmakers this season.
• The moneyline for this contest implies a 63.1% chance of a victory for the Guardians.
• The White Sox have been chosen as underdogs in 146 games this year and have walked away with the win 56 times (38.4%) in those games.
• Chicago has a win-loss record of 25-53 when favored by +144 or worse by oddsmakers this year.
• The White Sox have an implied victory probability of 41% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians have a 4-1 record over the five games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings, the Guardians and their opponents combined to hit the over two times (all 10 of the games had set totals).
• The Guardians are 8-2-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez paces the Guardians with 28 home runs and 77 runs batted in, while putting up a team-best batting average of .283.
• Among all MLB hitters, Ramirez is 19th in batting average, 27th in on-base percentage, and 17th in slugging.
• Steven Kwan has 26 doubles, a triple, 10 home runs and 51 walks while batting .275.
• Kwan is 193rd in home runs and 169th in RBI among all major league hitters this year.
• Kyle Manzardo is hitting .239 with 15 doubles, two triples, 26 home runs and 46 walks.
• Angel Martinez is hitting .226 with 21 doubles, a triple, 11 home runs and 19 walks.

Guardians Team Props

White Sox Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 7-3.
• In their last 10 games with a total, the White Sox and their opponents are 6-4-0 when it comes to hitting the over.
• The White Sox have eight wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is batting .231 with 30 doubles, two triples, 14 home runs and 50 walks.
• Vargas ranks 140th in home runs and 141st in RBI among all hitters in MLB.
• Andrew Benintendi is batting .246 with 16 doubles, two triples, 19 home runs and 37 walks.
• Among all MLB hitters, Benintendi ranks 78th in homers and 104th in RBI.
• Lenyn Sosa leads the White Sox with 20 home runs and 67 runs batted in, while generating a club-best batting average of .263.
• Chase Meidroth is hitting .269 with 15 doubles, four home runs and 43 walks.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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