Brewers vs. Padres Prediction, Odds, Picks - September 23

Christian Yelich and Fernando Tatis Jr. will be among the stars on display when the Milwaukee Brewers face the San Diego Padres on Tuesday at 9:40 p.m. ET, at PETCO Park. The Brewers are the favorite in this one, at -128, while the underdog Padres have +108 odds to win. Milwaukee is a 1.5-run favorite (at +134 odds). The total is 8 runs for the game (with -112 odds on the over and -108 odds on the under).

Here's everything you need from a betting perspective on the Brewers-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Padres Game Information & Odds

• When: Tuesday, September 23, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and FDSWI

Brewers vs. Padres Prediction

• Score Prediction: Brewers 5, Padres 4
• Total Prediction: Over 8 runs
• Win Probabilities: Brewers 51%, Padres 49%

Brewers vs. Padres Betting Insights

• This season, the Brewers have won 59 out of the 93 games, or 63.4%, in which they've been favored.
• Milwaukee is 46-18 this season when entering a game favored by -128 or more on the moneyline.
• The moneyline for this contest implies a 56.1% chance of a victory for the Brewers.
• The Padres have been victorious in 34, or 50%, of the 68 contests they have been chosen as underdogs in this season.
• This season, San Diego has been victorious 21 times in 46 chances when named as an underdog of at least +108 or longer on the moneyline.
• The moneyline set for this matchup implies the Padres have a 48.1% chance of walking away with the win.

Brewers Recent Betting Performance

• The Brewers have a 6-4 record from the 10 games they were favored on the moneyline over their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Brewers and their opponents combined to hit the over on the total six times.
• The Brewers' ATS record is 4-6-0 over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• William Contreras is batting .263 with 28 doubles, 17 home runs and 84 walks.
• In all of the majors, Contreras is 109th in homers and 59th in RBI.
• Yelich's 29 home runs and 102 RBI both pace his team.
• Yelich ranks 29th in home runs in MLB, and 11th in RBI.
• Brice Turang is batting .286 with 26 doubles, two triples, 18 home runs and 62 walks.
• Jackson Chourio is batting .272 with 34 doubles, four triples, 20 home runs and 28 walks.

Brewers Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in four of their past 10 games and won two of those contests.
• The Padres and their opponents have combined to hit the over six times in their last 10 games with a total.
• The Padres have a record of 5-5-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis is batting .267 with 27 doubles, two triples, 23 home runs and 88 walks, while getting on base at a rate of .367.
• Among all batters in the majors, Tatis' home run total ranks 56th and his RBI tally is 95th.
• Tatis carries a five-game hitting streak into this matchup. In his last five games he is batting .381 with a home run, two walks and an RBI.
• Manny Machado has hit 26 home runs with 93 RBI, leading the team in both categories.
• Machado ranks 39th overall in home runs and 21st in RBI this year.
• Luis Arraez leads the Padres with a team-best batting average of .286.
• Ramon Laureano is hitting .282 with 26 doubles, two triples, 24 home runs and 35 walks.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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