West Virginia vs. Colorado Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 9:04 a.m. ET

Data Skrive

The Colorado Buffaloes (3-6) are 6.5-point underdogs in a road conference matchup with the West Virginia Mountaineers (3-6) on Saturday, November 8, 2025 at Mountaineer Field at Milan Puskar Stadium. The over/under is 53.5 in this matchup.

The Mountaineers beat the Houston Cougars, 45-35, in their last contest. The Buffaloes lost against the Arizona Wildcats in their most recent game, 52-17.

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West Virginia vs. Colorado Game Information & Odds

When: Saturday, November 8, 2025 at 12 p.m. ET
Location: Mountaineer Field at Milan Puskar Stadium in Morgantown, West Virginia
TV: TNT
Live Box Score on FOX Sports

West Virginia vs Colorado Betting Information updated as of November 8, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
West Virginia	-6.5 (-107)	-224	+185	53.5	-107	-116

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West Virginia vs. Colorado Prediction

Pick ATS: Colorado (+6.5)
Pick OU: Under (53.5)
Prediction: West Virginia 27, Colorado 26

Predictions are made by the Data Skrive betting model.

Learn more about the West Virginia Mountaineers vs. the Colorado Buffaloes game on FOX Sports!

West Virginia vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the matchup is Mountaineers 30, Buffaloes 24.
The Mountaineers have a 69.1% chance to win this meeting based on the moneyline's implied probability. The Buffaloes have a 35.1% implied probability.
West Virginia is 5-4-0 ATS this season.
Colorado is 4-5-0 ATS this year.

West Virginia vs. Colorado: 2025 Stats Comparison

	West Virginia	Colorado
Off. Points per Game (Rank)	23.2 (96)	22 (102)
Def. Points per Game (Rank)	30.4 (115)	30.1 (111)
Turnovers Allowed (Rank)	12 (81)	14 (110)
Turnovers Forced (Rank)	16 (17)	8 (98)

West Virginia 2025 Key Players

Name	Position	Stats
Scotty Fox Jr.	QB	623 YDS (59.1%) / 4 TD / 2 INT 145 RUSH YDS / 3 RUSH TD / 20.7 RUSH YPG
Cam Vaughn	WR	28 REC / 443 YDS / 4 TD / 49.2 YPG
Diore Hubbard	RB	264 YDS / 4 TD / 44 YPG / 3.4 YPC 9 REC / 59 REC YDS / 0 REC TD / 14.8 REC YPG
Nicco Marchiol	QB	720 YDS (67.3%) / 2 TD / 2 INT 56 RUSH YDS / 1 RUSH TD / 14 RUSH YPG
Fred Perry	DB	61 TKL / 5 TFL / 3 SACK
Chase Wilson	LB	34 TKL / 4 TFL / 3 SACK / 2 INT
Darrian Lewis	DB	49 TKL / 0 TFL / 2 INT / 2 PD
Reid Carrico	LB	41 TKL / 3 TFL / 1.5 SACK

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	1,242 YDS (63.1%) / 10 TD / 6 INT 294 RUSH YDS / 5 RUSH TD / 36.8 RUSH YPG
Omarion Miller	WR	28 REC / 521 YDS / 6 TD / 65.1 YPG
Joseph Williams	WR	27 REC / 386 YDS / 3 TD / 48.3 YPG
Micah Welch	RB	313 YDS / 2 TD / 34.8 YPG / 4 YPC
Jeremiah Brown	LB	45 TKL / 6 TFL / 2 SACK
Tawfiq Byard	DB	46 TKL / 1 TFL / 0.5 SACK / 1 INT
Keaten Wade	DL	31 TKL / 4 TFL / 2.5 SACK
D.J. McKinney	DB	28 TKL / 1 TFL / 1 INT / 1 PD