Missouri vs. Auburn Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

Data Skrive

Two of the nation's top defenses square off when the No. 16 Missouri Tigers (5-1) take college football's 16th-ranked scoring defense into a matchup with the Auburn Tigers (3-3), who have the No. 18 scoring defense, on Saturday, October 18, 2025. The Missouri Tigers are only 1.5-point favorites. The total for this matchup has been set at 43.5 points.

In their last game, the Missouri Tigers lost versus the Alabama Crimson Tide, 27-24. The Auburn Tigers lost against the Georgia Bulldogs in their last game, 20-10.

Keep up with college football all season on FOX Sports.

Missouri vs. Auburn Game Information & Odds

When: Saturday, October 18, 2025 at 7:45 p.m. ET
Location: Jordan-Hare Stadium in Auburn, Alabama
TV: SEC Network
Live Box Score on FOX Sports

Missouri vs Auburn Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Missouri	-1.5 (-105)	-114	-105	43.5	-111	-109

Missouri vs. Auburn Prediction

Pick ATS: Auburn (+1.5)
Pick OU: Over (43.5)
Prediction: Auburn 26, Missouri 23

Predictions are made by the Data Skrive betting model.

Learn more about the Missouri Tigers vs. the Auburn Tigers game on FOX Sports!

Missouri vs. Auburn Betting Insights

Per the spread and over/under, the implied score for the game is Missouri Tigers 22, Auburn Tigers 21.
The Missouri Tigers have a 53.3% chance to claim victory in this meeting per the moneyline's implied probability. The Auburn Tigers hold a 51.2% implied probability.
Missouri is 4-2-0 ATS this season.
Auburn has a record of 2-4-0 against the spread this year.

Missouri vs. Auburn: Head-to-Head

In their past two matchups, Auburn has a split 1-1 record against Missouri.
The last two times the Missouri Tigers have squared off with the Auburn Tigers, they have posted a 2-0 record against the spread. The scoring has yet to go over the point total.
Auburn has been outscored by 1 point in its last two tilts against Missouri.

Missouri vs. Auburn: 2025 Stats Comparison

	Missouri	Auburn
Off. Points per Game (Rank)	41.7 (11)	24.7 (98)
Def. Points per Game (Rank)	16.7 (16)	17 (18)
Turnovers Allowed (Rank)	6 (35)	2 (3)
Turnovers Forced (Rank)	5 (104)	5 (104)

Missouri 2025 Key Players

Name	Position	Stats
Ahmad Hardy	RB	782 YDS / 9 TD / 130.3 YPG / 6.8 YPC
Beau Pribula	QB	1,370 YDS (72.8%) / 11 TD / 5 INT 182 RUSH YDS / 4 RUSH TD / 30.3 RUSH YPG
Jamal Roberts	RB	400 YDS / 3 TD / 66.7 YPG / 7.5 YPC 9 REC / 98 REC YDS / 1 REC TD / 19.6 REC YPG
Brett Norfleet	TE	23 REC / 212 YDS / 5 TD / 35.3 YPG
Zion Young	DL	18 TKL / 4 TFL / 3 SACK
Damon Wilson Jr.	DL	10 TKL / 5 TFL / 5.5 SACK
Josiah Trotter	LB	34 TKL / 5 TFL
Khalil Jacobs	LB	19 TKL / 4 TFL / 3 SACK

Auburn 2025 Key Players

Name	Position	Stats
Jackson Arnold	QB	983 YDS (64.2%) / 5 TD / 0 INT 247 RUSH YDS / 6 RUSH TD / 41.2 RUSH YPG
Jeremiah Cobb	RB	453 YDS / 4 TD / 75.5 YPG / 6.5 YPC
Eric Singleton Jr.	WR	30 REC / 279 YDS / 2 TD / 46.5 YPG
Cam Coleman	WR	24 REC / 305 YDS / 2 TD / 50.8 YPG
Xavier Atkins	LB	31 TKL / 4 TFL / 3 SACK / 1 INT
Keyron Crawford	DL	15 TKL / 4 TFL / 4 SACK / 1 INT
Robert Woodyard Jr.	LB	20 TKL / 3 TFL / 2 SACK
Eric Winters	DB	11 TKL / 2 TFL / 1 SACK