Mississippi State vs. Northern Illinois Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

FOX Sports

The Northern Illinois Huskies (1-1) will look to prove oddsmakers wrong when they hit the field against the Mississippi State Bulldogs (3-0) on Saturday, September 20, 2025 as an overwhelming 23.5-point underdog. The total has been set at 48.5 points for this matchup.

In their last game, the Bulldogs won versus the Alcorn State Braves, 63-0. The Huskies lost versus the Maryland Terrapins in their last game, 20-9.

Keep up with college football all season on FOX Sports.

Mississippi State vs. Northern Illinois Game Information & Odds

When: Saturday, September 20, 2025 at 4:15 p.m. ET
Location: Davis Wade Stadium at Scott Field in Starkville, Mississippi
TV: SEC Network
Live Box Score on FOX Sports

Mississippi State vs Northern Illinois Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Mississippi State	-23.5 (-110)	-2500	+1150	48.5	-110	-110

Mississippi State vs. Northern Illinois Prediction

Pick ATS: Northern Illinois (+23.5)
Pick OU: Under (48.5)
Prediction: Mississippi State 30, Northern Illinois 9

Predictions are made by the Data Skrive betting model.

Learn more about the Mississippi State Bulldogs vs. the Northern Illinois Huskies game on FOX Sports!

Mississippi State vs. Northern Illinois Betting Insights

Per the spread and over/under, the implied score for the matchup is Bulldogs 36, Huskies 12.
The Bulldogs have a 96.2% chance to claim victory in this meeting per the moneyline's implied probability. The Huskies hold an 8.0% implied probability.
Mississippi State has compiled a perfect 3-0-0 record against the spread this season.
Northern Illinois has a record of 1-1-0 against the spread this season.

Mississippi State vs. Northern Illinois: 2025 Stats Comparison

	Mississippi State	Northern Illinois
Off. Points per Game (Rank)	40.3 (23)	14 (132)
Def. Points per Game (Rank)	12.3 (26)	18.5 (26)
Turnovers Allowed (Rank)	2 (27)	1 (10)
Turnovers Forced (Rank)	6 (14)	2 (96)

Mississippi State 2025 Key Players

Name	Position	Stats
Blake Shapen	QB	722 YDS (67.9%) / 6 TD / 2 INT 23 RUSH YDS / 1 RUSH TD / 7.7 RUSH YPG
Brenen Thompson	WR	15 REC / 278 YDS / 3 TD / 92.7 YPG
Da'Marion Bothwell	RB	170 YDS / 4 TD / 56.7 YPG / 5.7 YPC
Anthony Evans III	WR	17 REC / 210 YDS / 2 TD / 70 YPG
Will Whitson	DL	7 TKL / 4 TFL / 2 SACK
Brylan Lanier	DB	11 TKL / 0 TFL / 1 INT / 1 PD
Hunter Washington	DB	11 TKL / 0 TFL / 1 INT / 1 PD
Nic Mitchell	LB	15 TKL / 0 TFL

Northern Illinois 2025 Key Players

Name	Position	Stats
Chavon Wright	RB	167 YDS / 1 TD / 83.5 YPG / 4.4 YPC
Telly Johnson Jr.	RB	153 YDS / 1 TD / 76.5 YPG / 4.9 YPC
DeAree Rogers	WR	10 REC / 89 YDS / 0 TD / 44.5 YPG
Josh Holst	QB	192 YDS (65%) / 0 TD / 1 INT
Quinton Urwiler	LB	20 TKL / 0 TFL / 0.5 SACK
Muhammad Jammeh	DB	11 TKL / 0 TFL / 1 INT / 1 PD
Roy Williams	DL	6 TKL / 1 TFL / 1 SACK
Filip Maciorowski	LB	11 TKL / 0 TFL