Mississippi State vs. Northern Illinois Prediction, Odds, Picks - September 20, 2025

The Northern Illinois Huskies (1-1) will look to prove oddsmakers wrong when they hit the field against the Mississippi State Bulldogs (3-0) on Saturday, September 20, 2025 as an overwhelming 23.5-point underdog. The total has been set at 48.5 points for this matchup.

In their last game, the Bulldogs won versus the Alcorn State Braves, 63-0. The Huskies lost versus the Maryland Terrapins in their last game, 20-9.

Keep up with college football all season on FOX Sports.

Mississippi State vs. Northern Illinois Game Information & Odds

• When: Saturday, September 20, 2025 at 4:15 p.m. ET
• Location: Davis Wade Stadium at Scott Field in Starkville, Mississippi
• TV: SEC Network
• Live Box Score on FOX Sports

Mississippi State vs. Northern Illinois Prediction

• Pick ATS: Northern Illinois (+23.5)
  
• Pick OU: Under (48.5)
  
• Prediction: Mississippi State 30, Northern Illinois 9

Predictions are made by the Data Skrive betting model.

Learn more about the Mississippi State Bulldogs vs. the Northern Illinois Huskies game on FOX Sports!

Mississippi State vs. Northern Illinois Betting Insights

• Per the spread and over/under, the implied score for the matchup is Bulldogs 36, Huskies 12.
• The Bulldogs have a 96.2% chance to claim victory in this meeting per the moneyline's implied probability. The Huskies hold an 8.0% implied probability.
• Mississippi State has compiled a perfect 3-0-0 record against the spread this season.
• Northern Illinois has a record of 1-1-0 against the spread this season.

Mississippi State vs. Northern Illinois: 2025 Stats Comparison

Mississippi State 2025 Key Players

Northern Illinois 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.