James Madison vs. Louisiana Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 9:04 a.m. ET

Data Skrive

The James Madison Dukes (4-1) take college football's 11th-ranked rushing defense into a matchup with the Louisiana Ragin' Cajuns (2-3), who have the No. 23 rushing offense, on Saturday, October 11, 2025. The Dukes are heavy, 18.5-point favorites. The contest has a 45.5-point over/under.

In their most recent game, the Dukes won against the Georgia State Panthers, 14-7. In their most recent contest, the Ragin' Cajuns won versus the Marshall Thundering Herd, 54-51.

Keep up with college football all season on FOX Sports.

James Madison vs. Louisiana Game Information & Odds

When: Saturday, October 11, 2025 at 12 p.m. ET
Location: Bridgeforth Stadium/Zane Showker Field in Harrisonburg, Virginia
TV: ESPN2
Live Box Score on FOX Sports

James Madison vs Louisiana Betting Information updated as of October 11, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
James Madison	-18.5 (-110)	-1075	+690	45.5	-110	-110

James Madison vs. Louisiana Prediction

Pick ATS: James Madison (-18.5)
Pick OU: Over (45.5)
Prediction: James Madison 42, Louisiana 10

Predictions are made by the Data Skrive betting model.

Learn more about the James Madison Dukes vs. the Louisiana Ragin' Cajuns game on FOX Sports!

James Madison vs. Louisiana Betting Insights

Based on the spread and over/under, the implied score for the tilt is Dukes 32, Ragin' Cajuns 14.
The Dukes have a 91.5% chance to win this meeting per the moneyline's implied probability. The Ragin' Cajuns have a 12.7% implied probability.
James Madison is 4-1-0 ATS this season.
Louisiana has covered once in four games with a spread this year.

James Madison vs. Louisiana: 2025 Stats Comparison

	James Madison	Louisiana
Off. Points per Game (Rank)	27.8 (87)	28.2 (83)
Def. Points per Game (Rank)	13.6 (12)	32.2 (107)
Turnovers Allowed (Rank)	5 (35)	6 (54)
Turnovers Forced (Rank)	4 (106)	5 (89)

James Madison 2025 Key Players

Name	Position	Stats
Wayne Knight	RB	426 YDS / 4 TD / 85.2 YPG / 7 YPC 16 REC / 115 REC YDS / 0 REC TD / 23 REC YPG
Alonza Barnett III	QB	667 YDS (58.6%) / 4 TD / 1 INT 85 RUSH YDS / 5 RUSH TD / 17 RUSH YPG
Jordan Fuller	RB	262 YDS / 1 TD / 87.3 YPG / 6.4 YPC
Landon Ellis	WR	13 REC / 183 YDS / 2 TD / 36.6 YPG
Trent Hendrick	LB	20 TKL / 4 TFL / 3 SACK
Jacob Thomas	DB	13 TKL / 0 TFL / 1 SACK / 1 INT
Gannon Weathersby	LB	17 TKL / 1 TFL / 1 SACK
Aiden Gobaira	DL	6 TKL / 4 TFL / 2 SACK

Louisiana 2025 Key Players

Name	Position	Stats
Zylan Perry	RB	411 YDS / 5 TD / 82.2 YPG / 7 YPC
Elijah Davis	RB	314 YDS / 3 TD / 62.8 YPG / 5.1 YPC
Lunch Winfield	QB	129 YDS (42.9%) / 2 TD / 0 INT 148 RUSH YDS / 3 RUSH TD / 37 RUSH YPG
Steven Blanco	RB	125 YDS / 1 TD / 31.3 YPG / 6.9 YPC
Jaden Dugger	LB	31 TKL / 3 TFL / 1 SACK
Terrence Williams	LB	20 TKL / 2 TFL / 1 SACK
Courtline Flowers	DB	13 TKL / 2 TFL / 1 SACK / 1 INT
Jake St. Andre	LB	22 TKL / 1 TFL / 0.5 SACK