Duke vs. Virginia Prediction, Odds, Picks - November 15, 2025

Updated Nov. 15, 2025 3:04 p.m. ET

Data Skrive

The No. 20 Virginia Cavaliers (8-2) are 4.5-point underdogs in a road conference matchup with the Duke Blue Devils (5-4) on Saturday, November 15, 2025 at Brooks Field at Wallace Wade Stadium. A 60.5-point over/under is set for the game.

The Blue Devils lost against the UConn Huskies in their most recent game, 37-34. The Cavaliers lost versus the Wake Forest Demon Deacons in their last game, 16-9.

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Duke vs. Virginia Game Information & Odds

When: Saturday, November 15, 2025 at 3:30 p.m. ET
Location: Brooks Field at Wallace Wade Stadium in Wilmington, North Carolina
TV: ESPN2
Live Box Score on FOX Sports

Duke vs Virginia Betting Information updated as of November 15, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Duke	-4.5 (-115)	-200	+166	60.5	-110	-116

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Duke vs. Virginia Prediction

Pick ATS: Virginia (+4.5)
Pick OU: Under (60.5)
Prediction: Duke 31, Virginia 28

Predictions are made by the Data Skrive betting model.

Learn more about the Duke Blue Devils vs. the Virginia Cavaliers game on FOX Sports!

Duke vs. Virginia Betting Insights

Based on the spread and over/under, the implied score for the tilt is Blue Devils 32, Cavaliers 28.
The Blue Devils have a 66.7% chance to collect the win in this contest per the moneyline's implied probability. The Cavaliers hold a 37.6% implied probability.
Duke is 4-5-0 ATS this season.
Virginia has won six games against the spread this season, failing to cover four times.

Duke vs. Virginia: Head-to-Head

In their last three head-to-head matchups, Virginia has taken down Duke two times.
In those games against Duke, the Cavaliers have covered two times while outscoring the total on one occasion.
Over their last three head-to-head matchups, Virginia has scored 95 points, while Duke has tallied 65.

Duke vs. Virginia: 2025 Stats Comparison

	Duke	Virginia
Off. Points per Game (Rank)	35.2 (28)	33.7 (16)
Def. Points per Game (Rank)	29.1 (91)	21.6 (57)
Turnovers Allowed (Rank)	10 (41)	9 (23)
Turnovers Forced (Rank)	13 (46)	14 (39)

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	2,794 YDS (69.8%) / 24 TD / 4 INT
Nate Sheppard	RB	657 YDS / 7 TD / 73 YPG / 6.6 YPC 21 REC / 148 REC YDS / 1 REC TD / 16.4 REC YPG
Cooper Barkate	WR	50 REC / 824 YDS / 5 TD / 91.6 YPG
Anderson Castle	RB	362 YDS / 6 TD / 40.2 YPG / 5.5 YPC 12 REC / 81 REC YDS / 0 REC TD / 13.5 REC YPG
Caleb Weaver	DB	61 TKL / 3 TFL / 1.5 SACK / 1 INT
Vincent Anthony Jr.	DL	26 TKL / 9 TFL / 6.5 SACK
DaShawn Stone	DB	55 TKL / 0 TFL / 1 INT / 1 PD
Jaiden Francois	LB	47 TKL / 2 TFL / 1 SACK

Virginia 2025 Key Players

Name	Position	Stats
Chandler Morris	QB	2,088 YDS (66.7%) / 12 TD / 5 INT 214 RUSH YDS / 4 RUSH TD / 21.4 RUSH YPG
J'mari Taylor	RB	784 YDS / 11 TD / 78.4 YPG / 4.6 YPC 34 REC / 160 REC YDS / 0 REC TD / 16 REC YPG
Trell Harris	WR	43 REC / 605 YDS / 4 TD / 60.5 YPG
Cameron Ross	WR	35 REC / 395 YDS / 2 TD / 43.9 YPG
Kamren Robinson	LB	61 TKL / 2 TFL / 2 SACK / 2 INT
Mitchell Melton	DL	32 TKL / 2 TFL / 3.5 SACK / 1 INT
Daniel Rickert	DL	26 TKL / 5 TFL / 5.5 SACK
Devin Neal	DB	54 TKL / 1 TFL / 0.5 SACK