Arizona State vs. Colorado Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The Arizona State Sun Devils (7-3) visit the Colorado Buffaloes (3-7) on Saturday, November 22, 2025 in a matchup between Big 12 rivals at Folsom Field. Colorado is a touchdown underdog. A 47.5-point over/under is set for the game.

Facing the West Virginia Mountaineers in their most recent game, the Sun Devils won 25-23. The Buffaloes lost to the West Virginia Mountaineers, 29-22, in their most recent contest.

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Arizona State vs. Colorado Game Information & Odds

When: Saturday, November 22, 2025 at 8 p.m. ET
Location: Folsom Field in Boulder, Colorado
TV: ESPN2
Live Box Score on FOX Sports

Arizona State vs Colorado Betting Information updated as of November 22, 2025, 12:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Arizona State	-7 (-110)	-265	+213	47.5	-107	-113

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Arizona State vs. Colorado Prediction

Pick ATS: Arizona State (-7)
Pick OU: Over (47.5)
Prediction: Arizona State 30, Colorado 20

Predictions are made by the Data Skrive betting model.

Learn more about the Arizona State Sun Devils vs. the Colorado Buffaloes game on FOX Sports!

Arizona State vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the matchup is Sun Devils 27, Buffaloes 20.
The Sun Devils have a 72.6% chance to claim victory in this game per the moneyline's implied probability. The Buffaloes hold a 31.9% implied probability.
Arizona State is 4-5-1 ATS this season.
Colorado is 4-6-0 ATS this year.

Arizona State vs. Colorado: Head-to-Head

Over their last three meetings, Arizona State has put up two wins versus Colorado.
The two teams have gone over the total on two occasions while sharing a split 1-1-1 record in their meetings against the spread.
In their last three head-to-head matchups, Arizona State has tallied 101 points against Colorado, while surrendering only 74 points.

Arizona State vs. Colorado: 2025 Stats Comparison

	Arizona State	Colorado
Off. Points per Game (Rank)	24.7 (94)	22 (109)
Def. Points per Game (Rank)	23.6 (56)	30 (101)
Turnovers Allowed (Rank)	8 (8)	15 (92)
Turnovers Forced (Rank)	12 (72)	11 (87)

Arizona State 2025 Key Players

Name	Position	Stats
Sam Leavitt	QB	1,628 YDS (60.7%) / 10 TD / 3 INT 306 RUSH YDS / 5 RUSH TD / 43.7 RUSH YPG
Raleek Brown	RB	823 YDS / 3 TD / 82.3 YPG / 5.5 YPC 32 REC / 196 REC YDS / 1 REC TD / 19.6 REC YPG
Jordyn Tyson	WR	57 REC / 628 YDS / 8 TD / 89.7 YPG
Jeff Sims	QB	566 YDS (55.4%) / 5 TD / 1 INT 411 RUSH YDS / 2 RUSH TD / 68.5 RUSH YPG
Keyshaun Elliott	LB	76 TKL / 10 TFL / 5 SACK
Jordan Crook	LB	65 TKL / 7 TFL / 2 SACK / 1 INT
Myles Rowser	DB	61 TKL / 3 TFL
Adrian Wilson	DB	41 TKL / 1 TFL / 1 INT / 1 PD

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	1,242 YDS (63.1%) / 10 TD / 6 INT 294 RUSH YDS / 5 RUSH TD / 36.8 RUSH YPG
Omarion Miller	WR	34 REC / 652 YDS / 7 TD / 72.4 YPG
Joseph Williams	WR	30 REC / 450 YDS / 4 TD / 50 YPG
Micah Welch	RB	313 YDS / 2 TD / 31.3 YPG / 3.9 YPC
Jeremiah Brown	LB	56 TKL / 6 TFL / 2 SACK
Tawfiq Byard	DB	55 TKL / 2 TFL / 0.5 SACK / 1 INT
Keaten Wade	DL	35 TKL / 5 TFL / 2.5 SACK
Preston Hodge	DB	33 TKL / 1 TFL / 1 INT / 1 PD