2023 NFL Week 10 odds, predictions: Picks, lines, spreads for every game

The San Francisco 49ers (5-3) play at the Jacksonville Jaguars (6-2) in one of the marquee matchups of NFL Week 10 on Sunday.

The 49ers, coming off a bye, are the co-leaders of the NFC West Division with the Seattle Seahawks. 

The Jaguars lead the AFC South.

The game will be at 1 p.m. ET Sunday and can be seen on FOX and the FOX Sports App.

The New York Giants and Dallas Cowboys resume one of the league's most storied rivalries in Texas. The game is at 4:25 p.m. ET on Sunday and can be seen on FOX and the FOX Sports App.

Here's everything you need to know about the NFL odds for Week 10 — the point spread, moneyline and total Over/Under.

All times ET

BYES: Chiefs, Dolphins, Eagles, Rams

THURSDAY'S GAME

Panthers @ Bears (8:15 p.m., Amazon Prime Video)

Point spread: Bears -3 (Bears favored to win by more than 3 points, otherwise Panthers cover)
Moneyline: Bears -160 favorites to win (bet $10 to win $16.25 total); Panthers +135 underdogs to win (bet $10 to win $23.50 total)
Total scoring Over/Under: 40.5 points scored by both teams combined

Josh Dobbs reflects on being traded to the Vikings, leading them to a win

SUNDAY'S GAMES

Colts vs. Patriots @ Frankfurt, Germany (9:30 a.m., NFL Network)

Point spread: Colts -1.5 (Colts favored to win by more than 1.5 points, otherwise Patriots cover)
Moneyline: Colts -127 favorites to win (bet $10 to win $17.87 total); Patriots +107 underdogs to win (bet $10 to win $20.70 total)
Total scoring Over/Under: 43.5 points scored by both teams combined

Saints @ Vikings (1 p.m., FOX and FOX Sports App)

Point spread: Saints -2.5 (Saints favored to win by more than 2.5 points, otherwise Vikings cover)
Moneyline: Saints -143 favorites to win (bet $10 to win $16.99 total); Vikings +121 underdogs to win (bet $10 to win $22.10 total)
Total scoring Over/Under: 40.5 points scored by both teams combined

49ers @ Jaguars (1 p.m., FOX and FOX Sports App)

Point spread: 49ers -2.5 (49ers favored to win by more than 2.5 points, otherwise Jaguars cover)
Moneyline: 49ers -149 favorites to win (bet $10 to win $16.71 total); Jaguars +125 underdogs to win (bet $10 to win $22.50 total)
Total scoring Over/Under: 44.5 points scored by both teams combined

Browns @ Ravens (1 p.m., FOX and FOX Sports App)

Point spread: Ravens -5.5 (Ravens favored to win by more than 5.5 points, otherwise Browns cover)
Moneyline: Ravens -236 favorites to win (bet $10 to win $14.24 total); Browns +194 underdogs to win (bet $10 to win $29.40 total)
Total scoring Over/Under: 39 points scored by both teams combined

Texans @ Bengals (1 p.m., CBS)

Point spread: Bengals -8 (Bengals favored to win by more than 8 points, otherwise Texans cover)
Moneyline: Bengals -413 favorites to win (bet $10 to win $12.42 total); Texans +320 underdogs to win (bet $10 to win $42 total)
Total scoring Over/Under: 46.5 points scored by both teams combined

Packers @ Steelers (1 p.m., CBS)

Point spread: Steelers -3 (Steelers favored to win by more than 3 points, otherwise Packers cover)
Moneyline: Steelers -164 favorites to win (bet $10 to win $16.10 total); Packers +138 underdogs to win (bet $10 to win $23.80 total)
Total scoring Over/Under: 37 points scored by both teams combined

Titans @ Buccaneers (1 p.m., CBS)

Point spread: Buccaneers -1 (Buccaneers favored to win by more than 1 point, otherwise Titans cover)
Moneyline: Buccaneers -117 favorites to win (bet $10 to win $18.55 total); Titans -103 underdogs to win (bet $10 to win $19.71 total)
Total scoring Over/Under: 39 points scored by both teams combined

Falcons @ Cardinals (4:05 p.m., CBS)

Point spread: Falcons -2.5 (Falcons favored to win by more than 2.5 points, otherwise Cardinals cover)
Moneyline: Falcons -130 favorites to win (bet $10 to win $17.69 total); Cardinals +109 underdogs to win (bet $10 to win $20.90 total)
Total scoring Over/Under: 41.5 points scored by both teams combined

Lions @ Chargers (4:05 p.m., CBS)

Point spread: Lions -1.5 (Lions favored to win by more than 1.5 points, otherwise Chargers cover)
Moneyline: Lions -120 favorites to win (bet $10 to win $18.33 total); Chargers +101 underdogs to win (bet $10 to win $20.10 total)
Total scoring Over/Under: 48.5 points scored by both teams combined

Giants @ Cowboys (4:25 p.m., FOX and FOX Sports App)

Point spread: Cowboys -15.5 (Cowboys favored to win by more than 15.5 points, otherwise Giants cover)
Moneyline: Cowboys -1039 favorites to win (bet $10 to win $10.96 total); Giants +660 underdogs to win (bet $10 to win $76 total)
Total scoring Over/Under: 39.5 points scored by both teams combined

Commanders @ Seahawks (4:25 p.m., FOX and FOX Sports App)

Point spread: Seahawks -6 (Seahawks favored to win by more than 6 points, otherwise Commanders cover)
Moneyline: Seahawks -261 favorites to win (bet $10 to win $13.83 total); Commanders +209 underdogs to win (bet $10 to win $30.90 total)
Total scoring Over/Under: 44.5 points scored by both teams combined

Jets @ Raiders (8:20 p.m., NBC)

Point spread: Jets -2 (Jets favored to win by more than 2 points, otherwise Raiders cover)
Moneyline: Jets -126 favorites to win (bet $10 to win $17.81 total); Raiders +107 underdogs to win (bet $10 to win $20.70 total)
Total scoring Over/Under: 36.5 points scored by both teams combined

MONDAY'S GAME

Broncos @ Bills (8:15 p.m. ET, ESPN/ABC)

Point spread: Bills -7.5 (Bills favored to win by more than 7.5 points, otherwise Broncos cover)
Moneyline: Bills -374 favorites to win (bet $10 to win $12.67 total); Broncos +297 underdogs to win (bet $10 to win $39.70 total)
Total scoring Over/Under: 45.5 points scored by both teams combined