Coach Jim O'Brien said the team's first-round pick from North Carolina will be a reserve, and the plan is to play him for about 16 minutes.
Hansbrough led North Carolina to the national championship last season. The Pacers need him because starting power forward Troy Murphy is out with a bruised lower back.
Danny Granger will move from small forward to Murphy's spot at power forward, and Dahntay Jones will start at small forward in Granger's place.
Mike Dunleavy (knee), Travis Diener (toe on left foot) and Jeff Foster (sore lower back) also are out for the Pacers.