Adam Waddell had a game-high 17 points, Leonard Washington scored 16 points and Luke Martinez scored 14 as Wyoming beat Colorado 65-54 on Friday night.
Spencer Dinwiddie had 16 and Andre Roberson and Carlon Brown had 10 each for Colorado, which saw its 27-game nonconference home win streak stopped.
Wyoming (9-1) came into the game ranked third in the nation in scoring defense, allowing 49.4 points a game. The Cowboys haven't yet allowed a team to score 60.
The Cowboys built a double-digit lead on the strength of a 13-0 run midway through the second half. Waddell started the surge with six points and Martinez hit his fourth 3-pointer to give Wyoming a 49-37 lead with 8:41 left.
The Buffaloes cut the lead to 56-51 with 2:01 left but Wyoming closed it out on the free-throw line.