Desmar Jackson scored 16 points and Wyoming used a 32-13 rebound advantage to defeat Denver 61-48 on Tuesday night.
Amath M'Baye had 11 points and a career-best nine rebounds for the Cowboys (4-6), while JayDee Luster and Djibril Thiam added 10 points each.
Travis Hallam scored a career-high 17 points to pace the Pioneers (2-9), and Chase Hallam added 11.
M'Baye scored nine points in the first half to help Wyoming take a 24-16 lead at the break.
Denver closed to within 26-22 on a 3-pointer by Andrew Hooper before Luster's free throw with 15:07 left pushed the Cowboys' lead to 32-22. The Pioneers got no closer than seven the rest of the way.
Wyoming's lead reached 59-43 on a layup by Jackson with 47 seconds left.
There were 19 turnovers in the opening 12 minutes, and Wyoming used an 11-0 run to go up 20-11 late in the first half.