Steelers vs. Patriots 2025 Prediction, Odds, Picks - Sep 21

The Pittsburgh Steelers (1-1) are considered favorites (-1.5) according to the point spread ahead of their game against the New England Patriots (1-1) on September 21, 2025, starting at 1 p.m. ET, airing on CBS. An over/under of 44.5 points has been established for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

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Steelers vs. Patriots Odds & Betting Lines

Steelers vs. Patriots Prediction & Pick

• Pick ATS: Steelers (-1.5)
  
• Pick OU: Under (44.5)
  
• Prediction: Steelers 25 - Patriots 17

How to Watch Pittsburgh vs. New England

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: Gillette Stadium
• Location: Foxborough, Massachusetts
• TV: CBS
• Live Boxscore: FOX Sports

Steelers vs. Patriots Recent Matchups

• Over their last five meetings, New England has totaled four wins versus Pittsburgh.
• Over their last five head-to-head matchups, New England has racked up 108 points, while Pittsburgh has posted 76.

Pittsburgh Betting Info

• So far this season, Pittsburgh is winless versus the spread.
• The Steelers have been favored by 1.5 points or more this season twice, and failed to cover both times.
• Pittsburgh games this year have gone over the total in two out of two opportunities.
• The Steelers have been moneyline favorites in two other matchups this season, and they split them.
• The implied probability in this matchup, considering the moneyline, gives the Steelers a 55.0% chance to win.

Steelers Stats

Pittsburgh's Key Players

Offense

• Aaron Rodgers has passed for 447 yards, five touchdowns (third in the NFL) and two interceptions this year. He is averaging 223.5 yards per game and 7.1 per attempt, while completing 63.5% of his attempts.
• Jaylen Warren's rushing statline this season includes 85 yards but no touchdowns. He's averaging 42.5 yards per game and 3.4 per attempt (36th in the NFL).
• He has also hauled in six passes (on six targets) for 108 receiving yards with one touchdown. He's averaging 54.0 receiving yards and 3.0 catches per game.
• In the passing attack, D.K. Metcalf, has racked up 103 receiving yards and one touchdown after hauling in seven balls on 13 targets. Per game, he's averaging 51.5 yards and 3.5 receptions in two games.
• Calvin Austin III has five catches for 92 yards and one touchdown. He's been targeted 10 times in the passing game, and averages 2.5 receptions and 46.0 yards through two games played.

Defense

• On the defensive side, Payton Wilson has 14 tackles, 2.0 TFL, and one sack in 2025.
• Chuck Clark has 1.0 TFL and 13 tackles.
• This season, Jalen Ramsey has recorded nine tackles and one interception.
• This season, Juan Thornhill has 15 tackles. He leads the Steelers in tackles.

New England Betting Info

• New England has covered the spread once in two games with a set spread.
• The Patriots covered the spread in their only game when underdogs by 1.5 points or more.
• New England games have gone over the total once this season.
• The Patriots won the only game they've played as the underdog this season.
• Bookmakers have implied with the moneyline set for this matchup that the Patriots have a 49.5% chance to win.

Patriots Stats

New England's Key Players

Offense

• Drake Maye is averaging 7.5 passing yards per attempt (12th in the NFL) and 258.5 yards per game this year, completing 71.0% of his passes on the way to 517 total yards (10th in the NFL), three touchdowns and one interception through two games.
• On the ground, Maye has added one rushing touchdown and 42 rushing yards (second on the Patriots).
• Rhamondre Stevenson is still looking for a rushing touchdown, while totaling 69 rushing yards (3.8 per carry and 34.5 per game).
• Stevenson has added seven receptions (3.5 per game) for 100 yards (50.0 per game), without a receiving touchdown. He's been targeted eight times in the passing attack.
• Kayshon Boutte has recorded 119 receiving yards and one touchdown on seven receptions, while being targeted nine times this season.
• Antonio Gibson has 30 rushing yards (fourth on the Patriots), without scoring a rushing touchdown, while averaging 15.0 yards per game and 5.0 per carry.

Defense

• So far in 2025, Harold Landry has put up 3.5 sacks to go with 4.0 TFL and eight tackles over two games. He ranks first in the NFL in sacks.
• Jaylinn Hawkins has one interception on top of 13 tackles, 2.0 TFL, one sack, and one pass defended. He's third in the league in interceptions.
• Over the 2025 season, Milton Williams has six tackles, 3.0 TFL, and two sacks through two games.
• Craig Woodson has 14 tackles and 2.0 TFL.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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