Jaguars vs. Bills 2025 Wild Card Round Prediction, Odds, Picks - Jan 11

Updated Jan. 11, 2026 12:44 p.m. ET

Data Skrive

In this year's AFC Playoffs, the Jacksonville Jaguars will play the Buffalo Bills. The Jaguars are slight favorites (-1.5). The game has an over/under of 51.5 points.

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Jaguars vs. Bills Odds & Betting Lines

Jaguars vs Bills Betting Information updated as of January 11, 2026, 11:33 a.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Jaguars	-1.5	-110	-110	51.5	-108	-112

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Jaguars vs. Bills Prediction & Pick

Pick ATS: Jaguars (-1.5)
Pick OU: Under (51.5)
Prediction: Jaguars 28 - Bills 20

How to Watch Jacksonville vs. Buffalo

Game date: Sunday, January 11, 2026
Time: 1 p.m. ET
Venue: EverBank Stadium
Location: Jacksonville, Florida
TV: CBS
Live Boxscore: FOX Sports

Jaguars vs. Bills Recent Matchups

In their past five head-to-head bouts, Jacksonville has taken down Buffalo three times.
In their last five head-to-head matchups, Buffalo has compiled 100 points against Jacksonville, while surrendering only 75 points.

Jacksonville Betting Info

Jacksonville has played 17 games, posting 12 wins against the spread.
When playing as at least 1.5-point favorites this season, the Jaguars have an ATS record of 7-2.
Jacksonville contests this year have eclipsed the over/under 58.8% of the time (10 times in 17 games with a set point total).
The Jaguars have won 88.9% of the time they have played as moneyline favorites (8-1).
The Jaguars have an implied win probability, based on the moneyline, of 55.0%.

Jaguars Stats

Stat	Average (Total)	Rank
Pass yards	222.3 (3,779)	12
Rush yards	115.1 (1,956)	20
Points scored	27.9 (474)	6
Pass yards against	218.1 (3,707)	21
Rush yards against	85.6 (1,455)	1
Points allowed	19.8 (336)	8

Jacksonville's Key Players

Offense

Trevor Lawrence has thrown for 4,007 yards (sixth in the NFL), 29 touchdowns (fifth in the NFL) and 12 interceptions this year. He averages 235.7 yards per game and 7.2 per attempt, while completing 60.9% of his passes.
He has also rushed for 359 yards (second on the Jaguars) and added nine touchdowns on the ground, while averaging 21.1 rushing yards per game.
Travis Etienne has totaled 1,107 rushing yards with seven touchdowns (65.1 yards per game through 17 games). His 4.3 yards per attempt rank 28th in the NFL.
He's caught 36 passes (on 52 targets) for 292 receiving yards with six touchdowns. He's averaging 17.2 receiving yards and 2.1 catches per game.
Parker Washington has five touchdown catches this season, and has 58 receptions for 847 yards on 95 targets, while averaging 3.6 catches and 52.9 yards per game.
Jakobi Meyers has 75 catches for 835 yards and three touchdowns. He's been targeted 110 times in the air attack, and averages 4.7 receptions and 52.2 yards through 16 games played.

Defense

On the defensive side for the Jaguars, Foyesade Oluokun has racked up 143 tackles, five TFL, one sack, and one interception in 2025.
Josh Hines-Allen has 49 tackles, 12 TFL, and eight sacks this season.
Devin Lloyd has put up 74 tackles, six TFL, 1.5 sacks, and five interceptions this year. He's third on the Jaguars in tackles.
Andrew Wingard has three TFL, 84 tackles, and one interception on the year.

Buffalo Betting Info

Buffalo is 8-9-0 against the spread this year.
The Bills have always covered the spread this season when underdogs by 1.5 points or more.
This year, Buffalo games have hit the over nine times.
The Bills have won both games they've played as underdogs this season.
Bookmakers have implied with the moneyline set for this matchup that the Bills have a 49.5% chance to win.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	216.6 (3,683)	15
Rush yards	159.6 (2,714)	1
Points scored	28.3 (481)	4
Pass yards against	156.9 (2,668)	1
Rush yards against	136.2 (2,315)	28
Points allowed	21.5 (365)	12

Buffalo's Key Players

Offense

In 16 games played this year, Josh Allen has totaled 3,668 passing yards, with 25 touchdowns (ninth in the NFL) against 10 interceptions and completing 69.3% of his attempts.
On the ground, Allen has added 14 rushing touchdowns and 579 rushing yards (second on the Bills).
James Cook has scored 12 rushing touchdowns, while totaling 1,621 rushing yards (5.2 per attempt and 95.4 per game).
Cook also has 33 catches for 291 yards (sixth on the Bills), with two receiving touchdowns. He has been targeted 40 times and averages 17.1 yards per game.
This season, Khalil Shakir has caught 72 passes for 719 receiving yards with four touchdowns in the passing game. He has been targeted 95 total times and is averaging 4.5 receptions per game through 16 games played.
Dalton Kincaid has 571 receiving yards and five touchdowns from 39 receptions after getting 49 targets.

Defense

Cole Bishop has amassed two sacks to go with four TFL, 85 tackles, and three interceptions through 16 games in 2025.
Greg Rousseau has 46 tackles, six TFL, and seven sacks.
In the 2025 campaign, Joey Bosa has 29 tackles, nine TFL, and five sacks through 15 games.
Matt Milano has totaled 3.5 sacks (third on the Bills) to go with seven TFL and 67 tackles through 12 games.