Jaguars vs. Bills 2025 Wild Card Round Prediction, Odds, Picks - Jan 11

Updated Jan. 10, 2026 2:44 a.m. ET

Data Skrive

In this year's AFC Playoffs, the Jacksonville Jaguars will play the Buffalo Bills. The Jaguars are slight favorites (-1.5). The predicted point total for the game is 51.5.

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Jaguars vs. Bills Odds & Betting Lines

Jaguars vs Bills Betting Information updated as of January 9, 2026, 6:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Jaguars	-1.5	-103	-129	51.5	-112	-108

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Jaguars vs. Bills Prediction & Pick

Pick ATS: Jaguars (-1.5)
Pick OU: Under (51.5)
Prediction: Jaguars 28 - Bills 20

How to Watch Jacksonville vs. Buffalo

Game date: Sunday, January 11, 2026
Time: 1 p.m. ET
Venue: EverBank Stadium
Location: Jacksonville, Florida
TV: CBS
Live Boxscore: FOX Sports

Jaguars vs. Bills Recent Matchups

Jacksonville has a 3-2 record against Buffalo in their last five matchups.
Over their last five head-to-head matchups, Buffalo has scored 100 points, while Jacksonville has accumulated 75.

Jacksonville Betting Info

Against the spread, Jacksonville is 12-5-0 this year.
The Jaguars have an ATS record of 7-2 when playing as at least 1.5-point favorites this season.
Jacksonville games this year have gone over the total in 10 out of 17 opportunities (58.8%).
When playing as the moneyline favorite, the Jaguars are 8-1, picking up a victory 88.9% of the time.
The implied probability in this matchup, considering the moneyline, gives the Jaguars a 51.9% chance to win.

Jaguars Stats

Stat	Average (Total)	Rank
Pass yards	222.3 (3,779)	12
Rush yards	115.1 (1,956)	20
Points scored	27.9 (474)	6
Pass yards against	218.1 (3,707)	21
Rush yards against	85.6 (1,455)	1
Points allowed	19.8 (336)	8

Jacksonville's Key Players

Offense

Trevor Lawrence has 4,007 passing yards (sixth in the NFL), 29 touchdowns (fifth in the NFL) and 12 interceptions this year. He has completed 60.9% of his attempts, averaging 235.7 yards per game and 7.2 per attempt.
To go along with his passing stats, Lawrence has 359 rushing yards (second on the Jaguars), with nine rushing touchdowns.
Travis Etienne's rushing output this season includes 1,107 yards and seven TDs. He is averaging 65.1 yards per game and 4.3 per attempt (28th in the NFL).
Etienne's 52 targets in the passing game have resulted in 36 catches (2.1 per game) for 292 yards (17.2 per game) and six touchdowns.
In the passing game, Parker Washington, has racked up 847 receiving yards and five touchdowns after hauling in 58 balls on 95 targets. Per game, he's averaging 52.9 yards and 3.6 receptions over 16 games.
Jakobi Meyers has 835 receiving yards and three touchdowns with 75 catches on 110 targets. He is averaging 4.7 receptions and 52.2 yards per game.

Defense

On the defensive side, Foyesade Oluokun has one sack to go with five TFL, 143 tackles, and one interception in 2025.
Josh Hines-Allen has 49 tackles, 12 TFL, eight sacks, and three passes defended.
Devin Lloyd has put up 74 tackles, six TFL, 1.5 sacks, and five interceptions this year.
So far this season, Andrew Wingard has 84 tackles, three TFL, and one interception.

Buffalo Betting Info

Buffalo has covered the spread eight times this season (8-9-0).
The Bills have been underdogs by 1.5 points or more two times this year and have covered the spread every time.
Buffalo games have gone over the total nine times this year.
The Bills have won both games they've played as underdogs this season.
The implied probability of a win by the Bills based on the moneyline is 52.8%.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	216.6 (3,683)	15
Rush yards	159.6 (2,714)	1
Points scored	28.3 (481)	4
Pass yards against	156.9 (2,668)	1
Rush yards against	136.2 (2,315)	28
Points allowed	21.5 (365)	12

Buffalo's Key Players

Offense

Josh Allen is averaging 8 passing yards per attempt (fifth in the NFL) and 229.3 yards per game this year, completing 69.3% of his passes on the way to 3,668 total yards, 25 touchdowns (ninth in the NFL) and 10 interceptions through 16 games.
On the ground, Allen has added 14 rushing touchdowns and 579 rushing yards (second on the Bills).
James Cook averages 95.4 rushing yards per game through 17 games (1,621 total yards to rank first in the NFL), while scoring 12 rushing touchdowns.
Cook has added 33 receptions (1.9 per game) for 291 yards (17.1 per game) with two receiving touchdowns. He's been targeted 40 times in the passing attack.
In 16 games played this season, Khalil Shakir has 72 catches (4.5 receptions per game on 5.9 targets per game) for 719 yards and four receiving touchdowns.
Dalton Kincaid has 571 receiving yards and five touchdowns from 39 receptions after getting 49 targets.

Defense

So far in 2025, Cole Bishop has amassed 85 tackles, four TFL, two sacks, and three interceptions through 16 games.
Greg Rousseau has seven sacks (first on the Bills) to go with six TFL and 46 tackles.
Joey Bosa has five sacks (second on the Bills) in addition to his nine TFL and 29 tackles.
Matt Milano has put up 3.5 sacks (third on the Bills) to go with seven TFL and 67 tackles through 12 games.