Reds vs. Cubs Prediction, Odds, Picks - September 21

Will Benson and the Cincinnati Reds take the field on Sunday at Great American Ball Park against Jameson Taillon, who is starting for the Chicago Cubs. First pitch is set for 1:40 p.m. ET for the final game of a four-game series. The favored Reds have -120 moneyline odds against the underdog Cubs, who are listed at +101. Chicago (-1.5) is favored on the run line. The total for the game is set at 9 runs.

Here's everything you need to know from a betting perspective on the Reds-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Reds Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs vs. Cincinnati Reds.

Reds vs. Cubs Game Information & Odds

• When: Sunday, September 21, 2025 at 1:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: MLB Network, FDSOH, and MARQ+

Reds vs. Cubs Prediction

• Score Prediction: Reds 5, Cubs 4
• Total Prediction: Under 9 runs
• Win Probabilities: Reds 51%, Cubs 49%

Reds vs. Cubs Betting Insights

• This season, the Reds have won 36 out of the 68 games, or 52.9%, in which they've been favored.
• This season Cincinnati has won 29 of its 54 games, or 53.7%, when favored by at least -120 on the moneyline.
• The moneyline for this contest implies a 54.5% chance of a victory for the Reds.
• The Cubs have won in 18, or 40.9%, of the 44 contests they have been named as odds-on underdogs this year.
• This season, Chicago has come away with a win 12 times in 28 chances when named as an underdog of at least +101 or worse on the moneyline.
• The moneyline set for this matchup implies the Cubs have a 49.8% chance of coming away with a victory in the contest.

Reds Recent Betting Performance

• The Reds went 3-3 across the six games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups (all 10 of them had set totals), the Reds and their opponents combined to go over the run total four times.
• The Reds' ATS record is 5-5-0 over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz is the Reds RBI leader this season, driving in 83 runs to go with his 20 home runs and .262 batting average.
• De La Cruz's home runs place him 76th in the majors, and he ranks 33rd in RBI.
• De La Cruz carries a two-game hitting streak into this matchup. In his last five games he is batting .231 with a double, a home run, five walks and an RBI.
• TJ Friedl is batting .259 with 20 doubles, two triples, 13 home runs and 76 walks.
• Friedl is 156th in homers and 163rd in RBI among all hitters in baseball.
• Friedl carries a two-game streak with at least one hit into this contest. In his last five games he is batting .211 with a home run, two walks and three RBIs.
• Spencer Steer has a team-high 21 home runs.
• Steer will look to build on his two-game hitting in this matchup. During his last five outings he is batting .389 with four home runs, a walk and 10 RBIs.
• Austin Hays is batting .266 with 16 doubles, five triples, 15 home runs and 29 walks.

Reds Team Props

Cubs Recent Betting Performance

• The Cubs have played as underdogs in five of their past 10 games and have gone 2-3 in those contests.
• The Cubs and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Cubs are 7-3-0 ATS over their last 10 games.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner leads the Cubs with a .301 batting average.
• Hoerner's home run total places him 275th in MLB, and he is 121st in RBI.
• Pete Crow-Armstrong is hitting .246 with 37 doubles, four triples, 29 home runs and 29 walks.
• Crow-Armstrong ranks 28th among all batters in the majors in home runs, and 24th in RBI.
• Ian Happ has 29 doubles, 23 home runs and 85 walks while hitting .241.
• Seiya Suzuki has driven in the most runs for the Cubs with 91 runs batted in.

Cubs Team Props

Cubs vs. Reds Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs vs. Cincinnati Reds.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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