Padres vs. Pirates Prediction, Odds, Picks - May 31

Manny Machado and Oneil Cruz will be among the stars on display when the San Diego Padres play the Pittsburgh Pirates on Saturday at 9:40 p.m. ET, at PETCO Park. The Pirates are +120 moneyline underdogs in this matchup with the favorite Padres (-142). San Diego (-1.5) is the favorite on the run line. The over/under for the contest has been set at 8.5 runs.

Check out everything you need from a betting perspective on the Padres-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Padres Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the San Diego Padres!

Padres vs. Pirates Game Information & Odds

• When: Saturday, May 31, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and SportsNet PT

Padres vs. Pirates Prediction

• Score Prediction: Padres 4, Pirates 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Padres 56%, Pirates 44%

Padres vs. Pirates Betting Insights

• The Padres have been favorites in 32 games this season and won 20 (62.5%) of those contests.
• San Diego is 15-8 this season when entering a game favored by -142 or more on the moneyline.
• The Padres have a 58.7% chance to win this game based on the implied probability of the moneyline.
• The Pirates have come away with 15 wins in the 41 contests they have been listed as the underdogs in this season.
• Pittsburgh has a mark of 9-19 in contests where sportsbooks favor it by +120 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Pirates have a 45.5% chance of pulling out a win.

Padres Recent Betting Performance

• The Padres have a 3-3 record across the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Padres combined with their opponents to go over the total four times.
• The Padres are 3-7-0 against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr.'s 13 home runs in 2025 are the most on the Padres. He's also driven in 28 runs while hitting .269.
• Tatis' home runs rank him 13th in the majors, and he is 72nd in RBI.
• Machado is batting .314 to lead his team.
• Of all MLB hitters, Machado is 109th in homers and 92nd in RBI.
• Machado heads into this game looking for his eighth game in a row with a hit. In his last 10 games he is hitting .300 with three doubles, three home runs, three walks and five RBIs.
• Luis Arraez is hitting .289 with 10 doubles, three triples, three home runs and 10 walks.
• Arraez has at least one base hit in three games in a row. In his last five games he is batting .278 with two doubles, a walk and four RBIs.
• Gavin Sheets' 34 runs batted in pace his team.

Padres Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in nine of their past 10 games and have gone 5-4 in those contests.
• In their last 10 games with a total, the Pirates and their opponents are 5-5-0 when it comes to hitting the over.
• The Pirates have a record of 7-3-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Cruz has swatted a team-high 12 long balls.
• Among all hitters in the majors, Cruz's home run total ranks 19th and his RBI tally ranks 82nd.
• Bryan Reynolds has been productive as he paces his team with 32 RBI.
• Reynolds ranks 86th overall in homers and 38th in RBI this year.
• Isiah Kiner-Falefa is batting .297 with eight doubles, a triple, a home run and nine walks.
• Andrew McCutchen paces the Pirates with a .259 batting average.

Pirates Team Props

Pirates vs. Padres Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the San Diego Padres!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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