Guardians vs. Rangers Prediction, Odds, Picks - September 27

Jake Latz gets the nod for the Texas Rangers on Saturday at Progressive Field against Bo Naylor and the Cleveland Guardians. First pitch is at 7:15 p.m. ET for the second game of a three-game series. The Guardians are the favorite in this one, at -151, while the underdog Rangers have +126 odds to play spoiler. Cleveland is the run-line favorite (-1.5). The over/under for the contest is listed at 7 runs.

Here is everything you need from a betting perspective on the Guardians-Rangers game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Rangers Game Information & Odds

• When: Saturday, September 27, 2025 at 7:15 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: FOX

Guardians vs. Rangers Prediction

• Score Prediction: Guardians 4, Rangers 3
• Total Prediction: Over 7 runs
• Win Probabilities: Guardians 52%, Rangers 48%

Guardians vs. Rangers Betting Insights

• The Guardians have won 43, or 61.4%, of the 70 games they've played as favorites this season.
• Cleveland is 11-6 this season when entering a game favored by -151 or more on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 60.2%.
• The Rangers have won in 31, or 40.3%, of the 77 contests they have been named as odds-on underdogs this year.
• This year, Texas has won four of 18 games when listed as at least +126 or worse on the moneyline.
• The Rangers have an implied victory probability of 44.2% according to the moneyline set by sportsbooks for this matchup.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite in six of their last 10 games, and they finished 3-3 in those matchups.
• In their last 10 matchups, the Guardians and their opponents combined to go over the run total two times (all 10 games had set totals).
• The Guardians' ATS record is 7-3-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez is the bat to watch in the Guardians lineup, leading the team in batting average (.283), home runs (30), and RBI (85).
• In all of MLB, Ramirez ranks 28th in home runs and 37th in RBI.
• Steven Kwan is batting .274 with 29 doubles, a triple, 11 home runs and 54 walks.
• Kwan is 189th in homers in the majors, and 139th in RBI.
• Kyle Manzardo is hitting .232 with 18 doubles, two triples, 27 home runs and 48 walks.
• Angel Martinez is batting .226 with 23 doubles, two triples, 11 home runs and 22 walks.

Guardians Team Props

Rangers Recent Betting Performance

• The Rangers have been underdogs twice in the last 10 games and split those matchups 1-1.
• When it comes to hitting the over, the Rangers and their opponents are 4-6-0 in their last 10 games with a total.
• Over their last 10 games, the Rangers are 2-8-0 against the spread.

Rangers Recent Stats

Rangers Player Insights

• Adolis Garcia has driven in a team-leading 74 runs batted in.
• Garcia's home run total places him 104th in the majors, and he ranks 70th in RBI.
• Josh Jung has 21 doubles, a triple, 14 home runs and 26 walks while hitting .249.
• Jung ranks 149th among all hitters in MLB in homers, and 129th in RBI.
• Jake Burger is hitting .236 with 15 doubles, a triple, 16 home runs and 12 walks.
• Jonah Heim has 14 doubles, 11 home runs and 32 walks while batting .215.

Rangers Team Props

Twins vs. Rangers Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and Texas Rangers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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