Guardians vs. Athletics Prediction, Odds, Picks - June 22

The Athletics and Nick Kurtz take the field against Jose Ramirez and the Cleveland Guardians on Sunday at Sutter Health Park. Bookmakers list the Guardians as -135 favorites on the moneyline, while giving the underdog Athletics +114 moneyline odds. The Guardians are a 1.5-run favorite (at +120 odds). The total is 9.5 runs for the contest (with +101 odds to hit the over and -122 odds on the under).

Check out everything you need from a betting perspective on the Guardians-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Athletics Game Information & Odds

• When: Sunday, June 22, 2025 at 4:05 p.m. ET
• Where: Sutter Health Park in West Sacramento, California
• How to watch on TV: NBCS-CA and CLEG

Guardians vs. Athletics Prediction

• Score Prediction: Guardians 6, Athletics 5
• Total Prediction: Over 9.5 runs
• Win Probabilities: Guardians 51%, Athletics 49%

Guardians vs. Athletics Betting Insights

• The Guardians have won 16, or 59.3%, of the 27 games they've played as favorites this season.
• This season, the Guardians have won eight of their 11 games, or 72.7%, when favored by at least -135 on the moneyline.
• The moneyline for this contest implies a 57.4% chance of a victory for the Guardians.
• The Athletics have been chosen as underdogs in 61 games this year and have walked away with the win 23 times (37.7%) in those games.
• This year, the Athletics have won 12 of 43 games when listed as at least +114 or better on the moneyline.
• The Athletics have an implied victory probability of 46.7% according to the moneyline set by sportsbooks for this matchup.

Guardians Recent Betting Performance

• The Guardians went 1-2 across the three games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Guardians and their opponents combined to go over the total two times.
• The Guardians are 7-3-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the Guardians in home runs (13), runs batted in (36) and has a team-best batting average of .324.
• Of all batters in baseball, Ramirez is 36th in home runs and 74th in RBI.
• Ramirez brings a hitting streak of four games into this game. In his last five games he is hitting .316 with a double, two walks and two RBIs.
• Steven Kwan is hitting .305 with 17 doubles, six home runs and 25 walks.
• Among all major league hitters, Kwan ranks 163rd in homers and 171st in RBI.
• Kwan carries a three-game streak with at least one hit into this contest. During his last five outings he is hitting .368 with three doubles, two walks and an RBI.
• Carlos Santana has a team-best 36 runs batted in.
• Kyle Manzardo has 10 doubles, two triples, 11 home runs and 24 walks while batting .217.

Guardians Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in 10 of their past 10 games and won six of those contests.
• In their last 10 games with a total, the Athletics and their opponents have failed to hit the over six times.
• Over their last 10 games, the Athletics are 7-3-0 against the spread.

Athletics Recent Stats

Athletics Player Insights

• Jacob Wilson leads the Athletics with a .353 batting average.
• Among all hitters in the majors, Wilson is 92nd in homers and 49th in RBI.
• Brent Rooker's 15 home runs pace his team.
• Rooker is currently 22nd in home runs and 41st in RBI in the major leagues.
• Tyler Soderstrom has a team-high 45 runs batted in.
• Lawrence Butler has 23 doubles, a triple, 11 home runs and 27 walks while batting .261.

Athletics Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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