Diamondbacks vs. Astros Prediction, Odds, Picks - July 21

Eugenio Suarez and the Arizona Diamondbacks will try to find success Colton Gordon when he starts for the Houston Astros on Monday at 9:40 p.m. ET, in the first game of a three-game series at Chase Field. The favored Diamondbacks have -143 moneyline odds against the underdog Astros, who are listed at +119. Arizona is the run-line favorite (-1.5). The game's over/under is set at 9 runs.

Here is everything you need from a betting perspective on the Diamondbacks-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Astros Game Information & Odds

• When: Monday, July 21, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and SCHN

Diamondbacks vs. Astros Prediction

• Score Prediction: Diamondbacks 6, Astros 5
• Total Prediction: Over 9 runs
• Win Probabilities: Diamondbacks 51%, Astros 49%

Diamondbacks vs. Astros Betting Insights

• This season, the Diamondbacks have been favored 64 times and won 33, or 51.6%, of those games.
• Arizona has a record of 16-14 in games when sportsbooks favor them by at least -143 on the moneyline.
• The moneyline for this contest implies a 58.8% chance of a victory for the Diamondbacks.
• The Astros have been chosen as underdogs in 31 games this year and have walked away with the win 18 times (58.1%) in those games.
• This year, Houston has won nine of 12 games when listed as at least +119 or worse on the moneyline.
• The Astros have an implied victory probability of 45.7% according to the moneyline set for this matchup.

Diamondbacks Recent Betting Performance

• The Diamondbacks have a 2-1 record from the three games they were moneyline favorites over their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Diamondbacks and their opponents combined to hit the over on the total six times.
• The Diamondbacks' ATS record is 7-3-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo is hitting .272 with 20 doubles, two triples, 10 home runs and 58 walks.
• In all of Major League Baseball, Perdomo is 130th in home runs and ninth in RBI.
• Perdomo has collected a hit in three straight games. In his last five games he is hitting .333 with a triple, three walks and seven RBIs.
• Eugenio Suarez has hit 35 home runs with 85 RBI. Both pace his team.
• Suarez is third in homers in MLB, and first in RBI.
• Suarez carries a five-game streak with at least one hit into this contest. In his last five games he is batting .500 with a double, six home runs, four walks and 10 RBIs.
• Josh Naylor leads the Diamondbacks with a team-high batting average of .292.
• Corbin Carroll is hitting .251 with 16 doubles, 13 triples, 21 home runs and 32 walks.
• Carroll is riding a two-game hitting streak into this one. During his last five outings he is batting .261 with two doubles, three triples, a walk and an RBI.

Diamondbacks Team Props

Astros Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Astros have a record of 2-2.
• When it comes to hitting the over, the Astros and their opponents are 6-3-1 in their last 10 games with a total.
• The Astros have a record of 4-6-0 ATS over their last 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has driven in the most runs for the Astros with 53 runs batted in.
• Altuve is 37th in home runs and 50th in RBI among all hitters in the big leagues.
• Yainer Diaz is batting .239 with 11 doubles, a triple, 13 home runs and 14 walks.
• Diaz is currently 76th in home runs and 111th in RBI in the big leagues.
• Cam Smith is hitting .270 with 17 doubles, two triples, seven home runs and 27 walks.
• Christian Walker is batting .227 with 12 doubles, a triple, 13 home runs and 25 walks.

Astros Team Props

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Check out the best moments between the Houston Astros and Seattle Mariners.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

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