Blue Jays vs. Astros Prediction, Odds, Picks - September 10

The Toronto Blue Jays and George Springer will take the field against the Houston Astros and Jeremy Pena at Rogers Centre on Wednesday, with the first pitch at 7:07 p.m. ET. The Astros are +129 moneyline underdogs for this matchup against the favorite Blue Jays (-154). Toronto is the run-line favorite (-1.5). The contest's over/under has been listed at 8.5 runs.

Here's everything you need to know from a betting perspective on the Blue Jays-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. Astros Game Information & Odds

• When: Wednesday, September 10, 2025 at 7:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: SNET and SCHN

Blue Jays vs. Astros Prediction

• Score Prediction: Blue Jays 5, Astros 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Blue Jays 55%, Astros 45%

Blue Jays vs. Astros Betting Insights

• The Blue Jays have won 41, or 58.6%, of the 70 games they've played as favorites this season.
• This season Toronto has won 21 of its 29 games, or 72.4%, when favored by at least -154 on the moneyline.
• The sportsbooks' moneyline implies a 60.6% chance of a victory for the Blue Jays.
• The Astros have won in 28, or 56%, of the 50 contests they have been named as odds-on underdogs this year.
• Houston has a mark of 7-2 in contests where bookmakers favor it by +129 or worse on the moneyline.
• The moneyline set for this matchup implies the Astros have a 43.7% chance of coming away with a victory in the contest.

Blue Jays Recent Betting Performance

• The Blue Jays went 3-2 across the five games they were moneyline favorites in their last 10 matchups.
• Over their last 10 matchups, the Blue Jays and their opponents combined to go over the total five times (all 10 games had set totals).
• The Blue Jays are 6-4-0 against the spread over their past 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. has 33 doubles, 23 home runs and 76 walks while batting .304.
• Guerrero is 47th in homers and 35th in RBI among all batters in baseball.
• Guerrero takes a hitting streak of eight games into this matchup. In his last 10 games he is hitting .439 with three doubles, two home runs, four walks and seven RBIs.
• Springer has hit 28 home runs to pace his team.
• Springer is 21st in homers and 52nd in RBI on the season.
• Springer heads into this game looking for his third game in a row with a hit. In his last five games he is batting .200 with a double, two home runs, three walks and two RBIs.
• Ernie Clement is hitting .275 with 28 doubles, two triples, nine home runs and 24 walks.
• Clement is on a four-game hitting streak entering this contest. During his last five outings he is batting .278 with three doubles, two walks and an RBI.
• Alejandro Kirk has 17 doubles, 12 home runs and 45 walks while hitting .291.

Blue Jays Team Props

Astros Recent Betting Performance

• The Astros have played as underdogs in six of their past 10 games and have gone 2-4 in those contests.
• When it comes to hitting the over, the Astros and their opponents are 4-5-1 in their last 10 games with a total.
• The Astros have four wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has swatted a team-high 24 home runs.
• Among all hitters in MLB, Altuve's home run total ranks 41st and his RBI tally is 67th.
• Pena has a club-leading .303 batting average.
• Pena is currently 125th in home runs and 126th in RBI in the major leagues.
• Yainer Diaz has 21 doubles, a triple, 18 home runs and 20 walks while batting .254.
• Carlos Correa has 24 doubles, 12 home runs and 38 walks while batting .274.

Astros Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Toronto Blue Jays

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