Athletics vs. Astros Prediction, Odds, Picks - September 23

Tyler Soderstrom and the Athletics will hit the field at Sutter Health Park against the Houston Astros and Jose Altuve on Tuesday. The Astros are -105 moneyline underdogs for this matchup against the favorite Athletics (-114). The Astros are favored on the run line (-1.5). The total for the game has been set at 10 runs.

Take a look at everything you need to know from a betting perspective on the Athletics-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Athletics vs. Astros Game Information & Odds

• When: Tuesday, September 23, 2025 at 10:05 p.m. ET
• Where: Sutter Health Park in West Sacramento, California
• How to watch on TV: NBCS-CA and SCHN

Athletics vs. Astros Prediction

• Score Prediction: Athletics 6, Astros 5
• Total Prediction: Under 10 runs
• Win Probabilities: Athletics 51%, Astros 49%

Athletics vs. Astros Betting Insights

• This season, the Athletics have won 17 out of the 38 games, or 44.7%, in which they've been favored.
• This season, the Athletics have won 13 of their 29 games, or 44.8%, when favored by at least -114 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Athletics have a 53.3% chance to win.
• The Astros have come away with 32 wins in the 56 contests they have been listed as the underdogs in this season.
• This season, the Astros have come away with a win 30 times in 52 chances when named as an underdog of at least -105 or longer on the moneyline.
• The moneyline set for this matchup implies the Astros have a 51.2% chance of coming away with a victory in the contest.

Athletics Recent Betting Performance

• The Athletics went 2-1 over the three games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Athletics and their opponents combined to hit the over three times.
• The Athletics' ATS record is 7-3-0 over their past 10 games.

Athletics Recent Stats

Athletics Player Insights

• Brent Rooker is hitting .265 with 40 doubles, three triples, 30 home runs and 61 walks.
• Among all hitters in baseball, Rooker's home run total ranks him 21st, and his RBI tally ranks him 30th.
• Tyler Soderstrom's 90 runs batted in lead his team.
• Soderstrom ranks 49th in homers and 24th in RBI among all major league hitters this season.
• Nick Kurtz has hit a team-best 33 homers.
• Jacob Wilson has a club-high .315 batting average.

Athletics Team Props

Astros Recent Betting Performance

• The Astros have played as underdogs in five of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Astros and their opponents are 6-4-0 when it comes to hitting the over.
• The Astros have five wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has swatted a team-leading 26 long balls.
• Altuve's home run total puts him 39th in MLB, and he is 63rd in RBI.
• Jeremy Pena's .304 batting average is a team-high mark.
• Pena is currently 109th in home runs and 106th in RBI in the major leagues.
• Yainer Diaz has 23 doubles, a triple, 19 home runs and 20 walks while hitting .256.
• Carlos Correa is hitting .273 with 27 doubles, 13 home runs and 41 walks.

Astros Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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