Virginia vs. Duke Prediction, Odds, Picks - December 6, 2025

Updated Dec. 5, 2025 3:04 p.m. ET

Data Skrive

In this year's ACC Championship Game the Virginia Cavaliers are the favorites, but by less than a touchdown (-4.5) over the Duke Blue Devils. Bank of America Stadium will host the matchup on December 6, 2025, starting at 8 p.m. ET on ABC. The total is 57.5 points for this matchup.

Facing the Virginia Tech Hokies in their most recent game, the Cavaliers won 27-7. Facing the Wake Forest Demon Deacons in their most recent game, the Blue Devils won 49-32.

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Virginia vs. Duke Game Information & Odds

When: Saturday, December 6, 2025 at 8 p.m. ET
Location: Bank of America Stadium in Charlotte, North Carolina
TV: ABC
Live Box Score on FOX Sports

Virginia vs Duke Betting Information updated as of December 5, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Virginia	-4.5 (-107)	-184	+154	57.5	-115	-105

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Virginia vs. Duke Prediction

Pick ATS: Virginia (-4.5)
Pick OU: Over (57.5)
Prediction: Virginia 31, Duke 27

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Cavaliers vs. the Duke Blue Devils game on FOX Sports!

Virginia vs. Duke Betting Insights

Per the spread and over/under, the implied score for the matchup is Cavaliers 31, Blue Devils 26.
The Cavaliers have a 64.8% chance to win this game per the moneyline's implied probability. The Blue Devils hold a 39.4% implied probability.
Virginia has compiled an 8-4-0 ATS record so far this year.
Duke has won five games against the spread this season, failing to cover or pushing seven times.

Virginia vs. Duke: Head-to-Head

Virginia holds a 3-1 record against Duke in their last four matchups.
In those games versus Duke, the Cavaliers have covered three times while outpacing the total on one occasion.
In their last four head-to-head matchups, Virginia has compiled 129 points versus Duke, while giving up only 82 points.

Virginia vs. Duke: 2025 Stats Comparison

	Virginia	Duke
Off. Points per Game (Rank)	33.2 (27)	34.6 (19)
Def. Points per Game (Rank)	20 (24)	29.4 (97)
Turnovers Allowed (Rank)	11 (17)	11 (17)
Turnovers Forced (Rank)	17 (46)	19 (32)

Virginia 2025 Key Players

Name	Position	Stats
J'mari Taylor	RB	997 YDS / 14 TD / 83.1 YPG / 4.8 YPC 39 REC / 219 REC YDS / 0 REC TD / 18.3 REC YPG
Chandler Morris	QB	2,586 YDS (65.9%) / 14 TD / 7 INT 248 RUSH YDS / 5 RUSH TD / 20.7 RUSH YPG
Trell Harris	WR	56 REC / 809 YDS / 5 TD / 67.4 YPG
Harrison Waylee	RB	422 YDS / 5 TD / 38.4 YPG / 4.9 YPC
Mitchell Melton	DL	37 TKL / 3 TFL / 5.5 SACK / 1 INT
Kamren Robinson	LB	61 TKL / 2 TFL / 2 SACK / 2 INT
Daniel Rickert	DL	32 TKL / 5 TFL / 6 SACK
Devin Neal	DB	63 TKL / 1 TFL / 0.5 SACK

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	3,450 YDS (67.5%) / 28 TD / 4 INT -53 RUSH YDS / 1 RUSH TD / -4.4 RUSH YPG
Nate Sheppard	RB	865 YDS / 9 TD / 72.1 YPG / 5.5 YPC 30 REC / 235 REC YDS / 1 REC TD / 19.6 REC YPG
Cooper Barkate	WR	63 REC / 978 YDS / 6 TD / 81.5 YPG
Anderson Castle	RB	435 YDS / 11 TD / 36.3 YPG / 4.6 YPC 17 REC / 111 REC YDS / 0 REC TD / 12.3 REC YPG
Caleb Weaver	DB	77 TKL / 3 TFL / 1.5 SACK / 1 INT
Luke Mergott	LB	68 TKL / 4 TFL / 1.5 SACK
DaShawn Stone	DB	68 TKL / 0 TFL / 2 INT / 2 PD
Vincent Anthony Jr.	DL	31 TKL / 9 TFL / 6.5 SACK