Virginia vs. Duke Prediction, Odds, Picks - December 6, 2025

Updated Dec. 6, 2025 3:04 p.m. ET

Data Skrive

The Duke Blue Devils are the underdogs, but by less than a touchdown (+3.5), in this season's ACC Championship Game, where they will oppose the Virginia Cavaliers. Bank of America Stadium will host the matchup on December 6, 2025, starting at 8 p.m. ET on ABC. The total is 58.5 points for this game.

The Cavaliers' last game was against the Virginia Tech Hokies, and they won by a score of 27-7. The Blue Devils' most recent contest was versus the Wake Forest Demon Deacons, and they won by a score of 49-32.

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Virginia vs. Duke Game Information & Odds

When: Saturday, December 6, 2025 at 8 p.m. ET
Location: Bank of America Stadium in Charlotte, North Carolina
TV: ABC
Live Box Score on FOX Sports

Virginia vs Duke Betting Information updated as of December 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Virginia	-3.5 (-114)	-183	+153	58.5	-108	-112

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Virginia vs. Duke Prediction

Pick ATS: Virginia (-3.5)
Pick OU: Under (58.5)
Prediction: Virginia 31, Duke 27

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Cavaliers vs. the Duke Blue Devils game on FOX Sports!

Virginia vs. Duke Betting Insights

Per the spread and over/under, the implied score for the tilt is Cavaliers 31, Blue Devils 28.
The Cavaliers have a 64.7% chance to win this contest based on the moneyline's implied probability. The Blue Devils have a 39.5% implied probability.
Virginia has won eight games against the spread this season, while failing to cover four times.
Duke has covered five times in 12 games with a spread this year.

Virginia vs. Duke: Head-to-Head

Over their last four meetings, Virginia has put up three wins versus Duke.
The last four times the Cavaliers have matched up against the Blue Devils, they have posted a 3-1 record against the spread. The scoring has gone over the total on one occasion.
Over their last four head-to-head contests, Virginia has racked up 129 points, while Duke has posted 82.

Virginia vs. Duke: 2025 Stats Comparison

	Virginia	Duke
Off. Points per Game (Rank)	33.2 (28)	34.6 (19)
Def. Points per Game (Rank)	20 (24)	29.4 (96)
Turnovers Allowed (Rank)	11 (17)	11 (17)
Turnovers Forced (Rank)	17 (46)	19 (33)

Virginia 2025 Key Players

Name	Position	Stats
J'mari Taylor	RB	997 YDS / 14 TD / 83.1 YPG / 4.8 YPC 39 REC / 219 REC YDS / 0 REC TD / 18.3 REC YPG
Chandler Morris	QB	2,586 YDS (65.9%) / 14 TD / 7 INT 248 RUSH YDS / 5 RUSH TD / 20.7 RUSH YPG
Trell Harris	WR	56 REC / 809 YDS / 5 TD / 67.4 YPG
Harrison Waylee	RB	422 YDS / 5 TD / 38.4 YPG / 4.9 YPC
Mitchell Melton	DL	37 TKL / 3 TFL / 5.5 SACK / 1 INT
Kamren Robinson	LB	61 TKL / 2 TFL / 2 SACK / 2 INT
Daniel Rickert	DL	32 TKL / 5 TFL / 6 SACK
Devin Neal	DB	63 TKL / 1 TFL / 0.5 SACK

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	3,450 YDS (67.5%) / 28 TD / 4 INT -53 RUSH YDS / 1 RUSH TD / -4.4 RUSH YPG
Nate Sheppard	RB	865 YDS / 9 TD / 72.1 YPG / 5.5 YPC 30 REC / 235 REC YDS / 1 REC TD / 19.6 REC YPG
Cooper Barkate	WR	63 REC / 978 YDS / 6 TD / 81.5 YPG
Anderson Castle	RB	435 YDS / 11 TD / 36.3 YPG / 4.6 YPC 17 REC / 111 REC YDS / 0 REC TD / 12.3 REC YPG
Caleb Weaver	DB	77 TKL / 3 TFL / 1.5 SACK / 1 INT
Luke Mergott	LB	68 TKL / 4 TFL / 1.5 SACK
DaShawn Stone	DB	68 TKL / 0 TFL / 2 INT / 2 PD
Vincent Anthony Jr.	DL	31 TKL / 9 TFL / 6.5 SACK