Southern Miss vs. South Alabama Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The South Alabama Jaguars (3-7) are slight, 1.5-point underdogs in a home Sun Belt matchup against the Southern Miss Golden Eagles (7-3) on Saturday, November 22, 2025 at Hancock Whitney Stadium. The over/under is set at 53.5 points for the contest.

The Golden Eagles' most recent contest was against the Texas State Bobcats, and they lost by a score of 41-14. Last time out, the Jaguars defeated the Louisiana-Monroe Warhawks, with 26-14 being the final score.

Keep up with college football all season on FOX Sports.

Southern Miss vs. South Alabama Game Information & Odds

When: Saturday, November 22, 2025 at 3:30 p.m. ET
Location: Hancock Whitney Stadium in Mobile, Alabama
TV: ESPN+
Live Box Score on FOX Sports

Southern Miss vs South Alabama Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Southern Miss	-1.5 (-102)	-114	-105	53.5	-108	-112

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Southern Miss vs. South Alabama Prediction

Pick ATS: Southern Miss (-1.5)
Pick OU: Over (53.5)
Prediction: Southern Miss 28, South Alabama 26

Predictions are made by the Data Skrive betting model.

Learn more about the Southern Miss Golden Eagles vs. the South Alabama Jaguars game on FOX Sports!

Southern Miss vs. South Alabama Betting Insights

Per the spread and over/under, the implied score for the matchup is Golden Eagles 28, Jaguars 26.
The Golden Eagles have a 53.3% chance to claim victory in this contest per the moneyline's implied probability. The Jaguars have a 51.2% implied probability.
Southern Miss has won five games against the spread this season, while failing to cover or pushing five times.
South Alabama has put together a 4-6-0 record against the spread this year.

Southern Miss vs. South Alabama: Head-to-Head

South Alabama has a 4-0 record against Southern Miss in their last four matchups.
In their past four meetings, each team has covered two times with those contests going over the point total on two occasions.
Over their last four head-to-head contests, South Alabama has racked up 148 points, while Southern Miss has tallied 44.

Southern Miss vs. South Alabama: 2025 Stats Comparison

	Southern Miss	South Alabama
Off. Points per Game (Rank)	30.5 (53)	25 (91)
Def. Points per Game (Rank)	25.9 (76)	28.1 (91)
Turnovers Allowed (Rank)	12 (54)	11 (43)
Turnovers Forced (Rank)	25 (2)	12 (72)

Southern Miss 2025 Key Players

Name	Position	Stats
Braylon Braxton	QB	2,186 YDS (67.3%) / 19 TD / 5 INT 220 RUSH YDS / 1 RUSH TD / 24.4 RUSH YPG
Jeffery Pittman	RB	548 YDS / 7 TD / 68.5 YPG / 4.4 YPC 16 REC / 81 REC YDS / 0 REC TD / 11.6 REC YPG
Elijah Metcalf	WR	40 REC / 541 YDS / 2 TD / 60.1 YPG
Matt Jones	RB	299 YDS / 4 TD / 29.9 YPG / 4 YPC
Chris Jones	LB	65 TKL / 3 TFL / 3.5 SACK / 1 INT
J'Mond Tapp	DL	43 TKL / 9 TFL / 5.5 SACK
Michael Montgomery	LB	59 TKL / 1 TFL / 1.5 SACK / 2 INT
Ian Foster	DB	34 TKL / 2 TFL / 1 SACK / 3 INT

South Alabama 2025 Key Players

Name	Position	Stats
Bishop Davenport	QB	1,826 YDS (66.8%) / 12 TD / 5 INT 281 RUSH YDS / 7 RUSH TD / 28.1 RUSH YPG
Kentrel Bullock	RB	814 YDS / 10 TD / 81.4 YPG / 4.5 YPC 11 REC / 48 REC YDS / 1 REC TD / 6 REC YPG
Devin Voisin	WR	53 REC / 688 YDS / 4 TD / 68.8 YPG
Keenan Phillips	RB	517 YDS / 1 TD / 51.7 YPG / 5.2 YPC
Tirrell Johnson Jr.	LB	40 TKL / 5 TFL / 1 SACK / 1 INT
Darius McKenzie	LB	48 TKL / 5 TFL / 1 SACK
Blayne Myrick	LB	46 TKL / 4 TFL
Christopher Wallace Jr.	DB	37 TKL / 2 TFL