Southern Miss vs. Jacksonville State Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers give the Southern Miss Golden Eagles (2-2) the advantage on Saturday, September 27, 2025 against the Jacksonville State Gamecocks (2-2). Southern Miss is favored by 3.5 points. The contest has an over/under of 55.5.

Last time out, the Golden Eagles fell to the Louisiana Tech Bulldogs, with 30-20 being the final score. In their last contest, the Gamecocks won against the Murray State Racers, 45-10.

Keep up with college football all season on FOX Sports.

Southern Miss vs. Jacksonville State Game Information & Odds

When: Saturday, September 27, 2025 at 7 p.m. ET
Location: M.M. Roberts Stadium in Hattiesburg, Mississippi
TV: ESPN+
Live Box Score on FOX Sports

Southern Miss vs Jacksonville State Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Southern Miss	-3.5 (-113)	-183	+152	55.5	-111	-109

Southern Miss vs. Jacksonville State Prediction

Pick ATS: Southern Miss (-3.5)
Pick OU: Under (55.5)
Prediction: Southern Miss 36, Jacksonville State 18

Predictions are made by the Data Skrive betting model.

Learn more about the Southern Miss Golden Eagles vs. the Jacksonville State Gamecocks game on FOX Sports!

Southern Miss vs. Jacksonville State Betting Insights

Based on the spread and over/under, the implied score for the game is Golden Eagles 30, Gamecocks 26.
The Golden Eagles have a 64.7% chance to collect the win in this meeting per the moneyline's implied probability. The Gamecocks hold a 39.7% implied probability.
Southern Miss has won two games against the spread this season.
Jacksonville State has a record of 2-2-0 against the spread this year.

Southern Miss vs. Jacksonville State: 2025 Stats Comparison

	Southern Miss	Jacksonville State
Off. Points per Game (Rank)	28.3 (69)	30.8 (58)
Def. Points per Game (Rank)	26.5 (92)	23 (74)
Turnovers Allowed (Rank)	3 (30)	3 (30)
Turnovers Forced (Rank)	6 (27)	6 (27)

Southern Miss 2025 Key Players

Name	Position	Stats
Braylon Braxton	QB	1,084 YDS (65.8%) / 9 TD / 3 INT 128 RUSH YDS / 0 RUSH TD / 32 RUSH YPG
Jeffery Pittman	RB	126 YDS / 2 TD / 42 YPG / 5 YPC 11 REC / 63 REC YDS / 0 REC TD / 21 REC YPG
Carl Chester	WR	13 REC / 244 YDS / 1 TD / 61 YPG
Micah Davis	WR	11 REC / 102 YDS / 3 TD / 25.5 YPG
J'Mond Tapp	DL	10 TKL / 3 TFL / 3 SACK
Josh Battle	DB	12 TKL / 1 TFL / 1 SACK
Chris Jones	LB	19 TKL / 0 TFL / 0.5 SACK
Garrick Ponder	LB	5 TKL / 3 TFL / 2 SACK

Jacksonville State 2025 Key Players

Name	Position	Stats
Cam Cook	RB	537 YDS / 4 TD / 134.3 YPG / 6 YPC 7 REC / 48 REC YDS / 0 REC TD / 16 REC YPG
Gavin Wimsatt	QB	557 YDS (56.3%) / 2 TD / 2 INT 215 RUSH YDS / 4 RUSH TD / 53.8 RUSH YPG
Brock Rechsteiner	WR	13 REC / 191 YDS / 2 TD / 47.8 YPG
Andrew Paul	RB	92 YDS / 2 TD / 46 YPG / 7.1 YPC 1 REC / 17 REC YDS / 0 REC TD / 17 REC YPG
Trevor Woods	DB	24 TKL / 0 TFL / 1 INT / 1 PD
Walker O'Steen	LB	18 TKL / 0 TFL / 1 INT / 1 PD
Kalib Alexander	DB	7 TKL / 1 TFL / 1 SACK
Emmanuel Oyebadejo	DL	11 TKL / 1 TFL / 1.5 SACK