Oregon vs. Oklahoma State Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 3:04 p.m. ET

FOX Sports

The No. 6 Oregon Ducks (1-0) are a heavy 28.5-point favorite heading into their matchup on Saturday, September 6, 2025 against the Oklahoma State Cowboys (1-0). The game has an over/under of 55.5 points.

Last time out, the Ducks defeated the Montana State Bobcats, with 59-13 being the final score. The Cowboys beat the Tennessee-Martin Skyhawks, 27-7, in their most recent contest.

Keep up with college football all season on FOX Sports.

Oregon vs. Oklahoma State Game Information & Odds

When: Saturday, September 6, 2025 at 3:30 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: CBS
Live Box Score on FOX Sports

Oregon vs Oklahoma State Betting Information updated as of September 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-28.5 (-107)	-8333	+1920	55.5	-109	-111

Oregon vs. Oklahoma State Prediction

Pick ATS: Oregon (-28.5)
Pick OU: Over (55.5)
Prediction: Oregon 48, Oklahoma State 11

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the Oklahoma State Cowboys game on FOX Sports!

Oregon vs. Oklahoma State Betting Insights

Based on the spread and over/under, the implied score for the matchup is Ducks 42, Cowboys 14.
The Ducks have a 98.8% chance to win this meeting per the moneyline's implied probability. The Cowboys have a 5.0% implied probability.
Oregon has won all one of its games against the spread this season.
Oklahoma State has not won against the spread this year in one opportunities.

Oregon vs. Oklahoma State: 2025 Stats Comparison

	Oregon	Oklahoma State
Off. Points per Game (Rank)	59 (13)	27 (70)
Def. Points per Game (Rank)	13 (50)	7 (20)
Turnovers Allowed (Rank)	0 (1)	0 (1)
Turnovers Forced (Rank)	0 (94)	1 (51)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	213 YDS (78.3%) / 3 TD / 0 INT 18 RUSH YDS / 0 RUSH TD / 18 RUSH YPG
Jordon Davison	RB	26 YDS / 3 TD / 26 YPG / 4.3 YPC
Noah Whittington	RB	68 YDS / 1 TD / 68 YPG / 6.8 YPC
Malik Benson	WR	5 REC / 51 YDS / 1 TD / 51 YPG
Matayo Uiagalelei	LB	2 TKL / 2 TFL / 2 SACK
Nasir Wyatt	LB	2 TKL / 1 TFL / 1 SACK
A'Mauri Washington	DL	5 TKL / 1 TFL
Aaron Flowers	DB	2 TKL / 0 TFL

Oklahoma State 2025 Key Players

Name	Position	Stats
Hauss Hejny	QB	96 YDS (50%) / 1 TD / 0 INT 27 RUSH YDS / 1 RUSH TD / 27 RUSH YPG
Gavin Freeman	WR	5 REC / 46 YDS / 1 TD / 46 YPG
Sesi Vailahi	RB	32 YDS / 1 TD / 32 YPG / 3.6 YPC 1 REC / 14 REC YDS / 0 REC TD / 14 REC YPG
Terrill Davis	WR	2 REC / 75 YDS / 0 TD / 75 YPG
Wendell Gregory	LB	3 TKL / 3 TFL / 3 SACK
Brandon Rawls	LB	11 TKL / 1 TFL / 1 SACK
Bryan McCoy	LB	15 TKL / 0 TFL
Jaleel Johnson	DL	4 TKL / 2 TFL