Oregon vs. Oklahoma State Prediction, Odds, Picks - September 6, 2025

The No. 6 Oregon Ducks (1-0) are a heavy 28.5-point favorite heading into their matchup on Saturday, September 6, 2025 against the Oklahoma State Cowboys (1-0). The game has an over/under of 55.5 points.

Last time out, the Ducks defeated the Montana State Bobcats, with 59-13 being the final score. The Cowboys beat the Tennessee-Martin Skyhawks, 27-7, in their most recent contest.

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Oregon vs. Oklahoma State Game Information & Odds

• When: Saturday, September 6, 2025 at 3:30 p.m. ET
• Location: Autzen Stadium in Eugene, Oregon
• TV: CBS
• Live Box Score on FOX Sports

Oregon vs. Oklahoma State Prediction

• Pick ATS: Oregon (-28.5)
  
• Pick OU: Over (55.5)
  
• Prediction: Oregon 48, Oklahoma State 11

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the Oklahoma State Cowboys game on FOX Sports!

Oregon vs. Oklahoma State Betting Insights

• Based on the spread and over/under, the implied score for the matchup is Ducks 42, Cowboys 14.
• The Ducks have a 98.8% chance to win this meeting per the moneyline's implied probability. The Cowboys have a 5.0% implied probability.
• Oregon has won all one of its games against the spread this season.
• Oklahoma State has not won against the spread this year in one opportunities.

Oregon vs. Oklahoma State: 2025 Stats Comparison

Oregon 2025 Key Players

Oklahoma State 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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