Oklahoma vs. Auburn Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

The No. 22 Auburn Tigers (3-0) are 6.5-point underdogs in a road conference matchup against the No. 11 Oklahoma Sooners (3-0) on Saturday, September 20, 2025 at Gaylord Family Oklahoma Memorial Stadium. An over/under of 47.5 is set in the contest.

Against the Temple Owls in their last contest, the Sooners won 42-3. Last time around, the Tigers defeated the South Alabama Jaguars, with 31-15 being the final score.

Keep up with college football all season on FOX Sports.

John Mateer & Dante Moore in Joel Klatt’s top QBs this season | Joel Klatt Show

Joel Klatt revisited his top QBs list from the preseason and revealed his new top 10 QBs. He explained why Oklahoma QB John Mateer is at the top and his current Heisman vote. Joel analyzed how Dante Moore has impressed him so far in the season.

Oklahoma vs. Auburn Game Information & Odds

When: Saturday, September 20, 2025 at 3:30 p.m. ET
Location: Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma
TV: ABC
Live Box Score on FOX Sports

Oklahoma vs Auburn Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oklahoma	-6.5 (-116)	-247	+201	47.5	-110	-110

Oklahoma vs. Auburn Prediction

Pick ATS: Oklahoma (-6.5)
Pick OU: Under (47.5)
Prediction: Oklahoma 30, Auburn 16

Predictions are made by the Data Skrive betting model.

Learn more about the Oklahoma Sooners vs. the Auburn Tigers game on FOX Sports!

Oklahoma vs. Auburn Betting Insights

Based on the spread and over/under, the implied score for the game is Sooners 27, Tigers 20.
The Sooners have a 71.2% chance to claim victory in this contest per the moneyline's implied probability. The Tigers have a 33.2% implied probability.
Oklahoma has won two games against the spread this season.
Auburn has won one game against the spread this season.

Oklahoma vs. Auburn: 2025 Stats Comparison

	Oklahoma	Auburn
Off. Points per Game (Rank)	33.7 (53)	37 (37)
Def. Points per Game (Rank)	6.3 (5)	14 (36)
Turnovers Allowed (Rank)	5 (104)	1 (10)
Turnovers Forced (Rank)	0 (130)	3 (69)

Oklahoma 2025 Key Players

Name	Position	Stats
John Mateer	QB	944 YDS (67.6%) / 5 TD / 3 INT 161 RUSH YDS / 4 RUSH TD / 53.7 RUSH YPG
Tory Blaylock	RB	168 YDS / 3 TD / 56 YPG / 5.4 YPC
Deion Burks	WR	17 REC / 225 YDS / 2 TD / 75 YPG
Keontez Lewis	WR	15 REC / 181 YDS / 2 TD / 60.3 YPG
Samuel Omosigho	LB	6 TKL / 1 TFL / 1.5 SACK
Taylor Wein	DL	4 TKL / 2 TFL / 1.5 SACK
Reggie Powers III	DB	4 TKL / 1 TFL / 1 SACK
Wyatt Gilmore	DL	1 TKL / 0 TFL / 1 SACK

Auburn 2025 Key Players

Name	Position	Stats
Jackson Arnold	QB	501 YDS (69.6%) / 4 TD / 0 INT 192 RUSH YDS / 4 RUSH TD / 64 RUSH YPG
Jeremiah Cobb	RB	314 YDS / 4 TD / 104.7 YPG / 6.8 YPC
Eric Singleton Jr.	WR	13 REC / 149 YDS / 2 TD / 49.7 YPG
Cam Coleman	WR	10 REC / 149 YDS / 1 TD / 49.7 YPG
Keyron Crawford	DL	9 TKL / 2 TFL / 3 SACK / 1 INT
Xavier Atkins	LB	7 TKL / 2 TFL / 2 SACK
Jared Smith	DL	2 TKL / 1 TFL / 2 SACK
Keldric Faulk	DL	4 TKL / 1 TFL / 1 SACK