Notre Dame vs. Syracuse Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

FOX Sports

The No. 9 Notre Dame Fighting Irish (8-2) are big 36.5-point favorites on Saturday, November 22, 2025 against the Syracuse Orange (3-7). A 50.5-point over/under is set for the game.

The Fighting Irish beat the Pittsburgh Panthers, 37-15, in their last game. The Orange's last game was versus the Miami (FL) Hurricanes, and they lost by a score of 38-10.

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Notre Dame vs. Syracuse Game Information & Odds

When: Saturday, November 22, 2025 at 3:30 p.m. ET
Location: Notre Dame Stadium in South Bend, Indiana
TV: NBC
Live Box Score on FOX Sports

Notre Dame vs Syracuse Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-36.5 (-111)	N/A	N/A	50.5	-112	-108

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Notre Dame vs. Syracuse Prediction

Pick ATS: Notre Dame (-36.5)
Pick OU: Over (50.5)
Prediction: Notre Dame 46, Syracuse 7

Predictions are made by the Data Skrive betting model.

Learn more about the Notre Dame Fighting Irish vs. the Syracuse Orange game on FOX Sports!

Notre Dame vs. Syracuse Betting Insights

Per the spread and over/under, the implied score for the game is Fighting Irish 44, Orange 7.
Notre Dame has compiled a 5-5-0 ATS record so far this year.
Syracuse has won four games against the spread this year, failing to cover or pushing six times.

Notre Dame vs. Syracuse: 2025 Stats Comparison

	Notre Dame	Syracuse
Off. Points per Game (Rank)	38.5 (12)	22.3 (107)
Def. Points per Game (Rank)	18.4 (17)	31.5 (110)
Turnovers Allowed (Rank)	10 (25)	20 (128)
Turnovers Forced (Rank)	19 (13)	10 (100)

Notre Dame 2025 Key Players

Name	Position	Stats
Jeremiyah Love	RB	1,135 YDS / 14 TD / 113.5 YPG / 6.4 YPC 26 REC / 274 REC YDS / 3 REC TD / 30.4 REC YPG
CJ Carr	QB	2,487 YDS (67.3%) / 21 TD / 6 INT 28 RUSH YDS / 3 RUSH TD / 2.8 RUSH YPG
Jadarian Price	RB	589 YDS / 9 TD / 58.9 YPG / 5.7 YPC 3 REC / 47 REC YDS / 1 REC TD / 11.8 REC YPG
Malachi Fields	WR	32 REC / 596 YDS / 5 TD / 59.6 YPG
Boubacar Traore	DL	30 TKL / 6 TFL / 5.5 SACK
Kyngstonn Viliamu-Asa	LB	37 TKL / 5 TFL / 3 SACK / 1 INT
Tae Johnson	DB	37 TKL / 0 TFL / 4 INT / 4 PD
Adon Shuler	DB	39 TKL / 2 TFL / 1 SACK / 2 INT

Syracuse 2025 Key Players

Name	Position	Stats
Steve Angeli	QB	1,352 YDS (62.8%) / 10 TD / 2 INT -32 RUSH YDS / 1 RUSH TD / -8 RUSH YPG
Yasin Willis	RB	558 YDS / 4 TD / 62 YPG / 4.3 YPC
Darrell Gill Jr.	WR	29 REC / 477 YDS / 5 TD / 47.7 YPG
Will Nixon	RB	326 YDS / 3 TD / 32.6 YPG / 4.2 YPC 20 REC / 157 REC YDS / 0 REC TD / 17.4 REC YPG
Braheem Long Jr.	DB	47 TKL / 2 TFL / 2 SACK / 1 INT
Gary Bryant III	LB	50 TKL / 4 TFL / 1 SACK
Antoine Deslauriers	LB	50 TKL / 2 TFL / 1 SACK
Demetres Samuel Jr.	DB	44 TKL / 3 TFL / 1 INT / 1 PD