Missouri vs. UMass Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

The No. 20 Missouri Tigers (4-0) are big 43.5-point favorites on Saturday, September 27, 2025 against the UMass Minutemen (0-3). A 57-point over/under is set for the contest.

The Tigers' last contest was against the South Carolina Gamecocks, and they won by a score of 29-20. The Minutemen's most recent contest was versus the Iowa Hawkeyes, and they lost by a score of 47-7.

Keep up with college football all season on FOX Sports.

Missouri vs. UMass Game Information & Odds

When: Saturday, September 27, 2025 at 7:30 p.m. ET
Location: Memorial Stadium/Faurot Field in Columbia, Missouri
TV: ESPNU
Live Box Score on FOX Sports

Missouri vs UMass Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Missouri	-43.5 (-111)	N/A	N/A	57	-110	-110

Missouri vs. UMass Prediction

Pick ATS: Missouri (-43.5)
Pick OU: Over (57)
Prediction: Missouri 54, UMass 3

Predictions are made by the Data Skrive betting model.

Learn more about the Missouri Tigers vs. the UMass Minutemen game on FOX Sports!

Missouri vs. UMass Betting Insights

Based on the spread and over/under, the implied score for the tilt is Tigers 50, Minutemen 7.
Missouri has covered three times in four matchups with a spread this season.
UMass has compiled a 0-3-0 record against the spread this year.

Missouri vs. UMass: 2025 Stats Comparison

	Missouri	UMass
Off. Points per Game (Rank)	46 (10)	14.3 (133)
Def. Points per Game (Rank)	16.8 (44)	38.7 (111)
Turnovers Allowed (Rank)	3 (30)	3 (30)
Turnovers Forced (Rank)	3 (96)	2 (116)

Missouri 2025 Key Players

Name	Position	Stats
Beau Pribula	QB	962 YDS (72.4%) / 8 TD / 2 INT 148 RUSH YDS / 3 RUSH TD / 37 RUSH YPG
Ahmad Hardy	RB	600 YDS / 6 TD / 150 YPG / 7.6 YPC
Jamal Roberts	RB	298 YDS / 2 TD / 74.5 YPG / 7.1 YPC 4 REC / 56 REC YDS / 1 REC TD / 18.7 REC YPG
Marquis Johnson	WR	16 REC / 253 YDS / 2 TD / 63.3 YPG
Zion Young	DL	11 TKL / 4 TFL / 2 SACK
Josiah Trotter	LB	24 TKL / 5 TFL
Damon Wilson Jr.	DL	7 TKL / 3 TFL / 3.5 SACK
Khalil Jacobs	LB	9 TKL / 2 TFL / 2 SACK

UMass 2025 Key Players

Name	Position	Stats
Jacquon Gibson	WR	24 REC / 258 YDS / 0 TD / 86 YPG
Rocko Griffin	RB	142 YDS / 1 TD / 47.3 YPG / 4.7 YPC
Grant Jordan	QB	248 YDS (63.2%) / 0 TD / 1 INT 10 RUSH YDS / 2 RUSH TD / 5 RUSH YPG
Brandon Hood	RB	42 YDS / 1 TD / 14 YPG / 2.6 YPC
Derrieon Craig	DL	21 TKL / 0 TFL
Marques White	DL	6 TKL / 3 TFL / 2 SACK
Tyler Martin	LB	16 TKL / 0 TFL / 1 INT / 1 PD
Timmy Hinspeter	LB	17 TKL / 1 TFL / 1 SACK